Results 191 to 200 of about 1,349,497 (315)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View. [PDF]

Plast Reconstr Surg Glob Open
Hilewitz D, Ganor O, Adler N, Olshinka A, Shilo Yaacobi D, Har-Shai L, Shay T, Icekson M, Ad-El D, Meshulam-Derazon S.   +9 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

ShapeAXI: Shape Analysis Explainability and Interpretability. [PDF]

Proc SPIE Int Soc Opt Eng
Prieto JC, Miranda F, Gurgel M, Anchling L, Hutin N, Barone S, Al Turkestani N, Aliaga A, Yatabe M, Bianchi J, Cevidanes L.   +10 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On preserving anatomical detail in statistical shape analysis for clustering: focus on left atrial appendage morphology. [PDF]

Front Netw Physiol
Lee MT, Martorana V, Md RI, Sivera R, Cook AC, Menezes L, Burriesci G, Torii R, Bosi GM.   +8 more
europepmc   +1 more source

Describing shell shape variations and sexual dimorphism of Golden Apple Snail, Pomacea caniculata (Lamarck, 1822) using geometric morphometric analysis

, 2017
C.C. Cabuga, R.P. Sularte, et al. M.C.O. Acob   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Neural plasticity in early potters: Shape analysis and TMS-EEG co-registration trace the rise of a new motor skill. [PDF]

PLoS One
Forte V, Sartori L, Visalli A, Yildirim M, Galati G, Vidale M, Faresin E, Vallesi A.   +7 more
europepmc   +1 more source

How Do Institutions Shape Productive Entrepreneurship Across Levels of Economic Development? A Multilevel Analysis

Kun Fu, José Ernesto Amorós, Erkko Autio, Donghyun Park, Yeng-May Tan, Yeng-May Tan   +5 more
openalex   +1 more source