Results 41 to 50 of about 34,013 (255)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multiple shape coexistence in the N = Z 84Mo nucleus [PDF]

EPJ Web of Conferences
The structure of the nucleus 84Mo has been studied using the projected generator coordinate method (PGCM) with the Gogny D1S interaction. The calculations incorporate a mixing of particle-number and angular-momentum projected intrinsic wave functions ...
Rodríguez Tomás R.
doaj   +1 more source

Magic numbers for shape coexistence [PDF]

HNPS Proceedings, 2019
The increasing deformation in atomic nuclei leads to the change of the classical magic numbers (2,8,20,28,50,82…) which dictate the arrangement of nucleons in complete shells. The magic numbers of the three-dimensional harmonic oscillator (2,8,20,40,70,…) emerge at deformations around ε=0.6.
Assimakis, I. E., Bonatsos, D., Martinou, A., Sarantopoulou, S., Peroulis, S., Mertzimekis, T., Minkov, N.   +6 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Various facets of shape coexistence in neutron-rich nuclei within a beyond-mean-field approach [PDF]

EPJ Web of Conferences
Multifaceted impact of shape coexistence and mixing on 96Y to 96Zr and 92Rb to 92Sr allowed and first-forbidden β− decay was investigated within the beyond-mean-field complex Excited Vampir variational model.
Petrovici Alexandrina, Andrei Oana
doaj   +1 more source

First observation of a shape isomer and a low-lying strongly-coupled prolate band in neutron-deficient semi-magic 187Pb

Physics Letters B, 2022
Prompt and delayed γ-ray spectroscopy of the neutron-deficient, semi-magic isotope 187Pb has been performed using the recoil-decay and isomer-decay tagging techniques at the Argonne Gas-Filled Analyzer.
W.Q. Zhang, A.N. Andreyev, Z. Liu, D. Seweryniak, H. Huang, Z.H. Li, J.G. Li, C.Y. Guo, D.T. Doherty, A.E. Barzakh, P. Van Duppen, J.G. Cubiss, B. Andel, S. Antalic, M. Block, A. Bronis, M.P. Carpenter, P. Copp, B. Ding, Z. Favier, F. Giacoppo, T.H. Huang, X.H. Yu, B. Kindler, F.G. Kondev, T. Lauritsen, G.S. Li, B. Lommel, H.Y. Lu, M. Al Monthery, P. Mošať, Y.F. Niu, C. Raison, W. Reviol, G. Savard, S. Stolze, G.L. Wilson, H.Y. Wu, Z.H. Wang, F.R. Xu, Q.B. Zeng, X.H. Zhou   +41 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Shape coexistence and isospin symmetry in A = 70 nuclei: Spectroscopy of the Tz = −1 nucleus 70Kr

Physics Letters B, 2018
Excited states in the Tz=−1 nucleus 70Kr have been populated using inelastic scattering of a radioactive 70Kr beam as well as one- and two-neutron removal reactions from 71,72Kr at intermediate beam energies. The level scheme of 70Kr was constructed from
K. Wimmer, W. Korten, T. Arici, P. Doornenbal, P. Aguilera, A. Algora, T. Ando, H. Baba, B. Blank, A. Boso, S. Chen, A. Corsi, P. Davies, G. de Angelis, G. de France, D.T. Doherty, J. Gerl, R. Gernhäuser, D. Jenkins, S. Koyama, T. Motobayashi, S. Nagamine, M. Niikura, A. Obertelli, D. Lubos, B. Rubio, E. Sahin, T.Y. Saito, H. Sakurai, L. Sinclair, D. Steppenbeck, R. Taniuchi, R. Wadsworth, M. Zielinska   +33 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source