Results 61 to 70 of about 34,013 (255)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Collectivity of the deformed structure in 96Zr from complementary Coulomb-excitation and β-decay measurements

Physics Letters B
The B(E2;22+→01+) value in 96Zr was determined from a Coulomb-excitation measurement with 12C and 16O beams performed at the Maier-Leibnitz Laboratory with a Q3D magnetic spectrograph.
M. Zielińska, P.E. Garrett, M. Rocchini, S. Pannu, A. Bergmaier, V. Bildstein, A.B. Calder, S.R. Dworatzek, V. Vedia, Z.T. Ahmed, C. Andreoiu, D.W. Annen, H. Asch, A.A. Avaa, G.C. Ball, S. Buck, R.J. Coleman, A. Diaz Varela, D.T. Doherty, J.T.H. Dowie, T. Faestermann, A.B. Garnsworthy, E.D. Geerlof, B. Greaves, A.L. Grimes, G. Hackman, R. Hertenberger, S.F. Hicks, D. Kalaydjieva, V. Karayonchev, T. La Marca, S. Lange, B. Lenardo, L. Maqungo, N. Marchini, B. Marlow, M.S. Martin, K.R. Mashtakov, E. McCourt, J.R. Murias, S. Murillo-Morales, A. Nannini, E.E. Peters, C.M. Petrache, C. Porzio, G. Richardson, M. Scheck, P. Spagnoletti, K. Stoychev, C.E. Svensson, E. Taddei, G. Tocabens, S. Triambak, M. Vandebrouck, R. Umashankar, S. Valbuena, K. Wrzosek-Lipska, F. Wu (吴桐安), T. Zidar   +58 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Shape coexistence and the role of axial asymmetry in 72Ge

Physics Letters B, 2016
The quadrupole collectivity of low-lying states and the anomalous behavior of the 02+ and 23+ levels in 72Ge are investigated via projectile multi-step Coulomb excitation with GRETINA and CHICO-2. A total of forty six E2 and M1 matrix elements connecting
A.D. Ayangeakaa, R.V.F. Janssens, C.Y. Wu, J.M. Allmond, J.L. Wood, S. Zhu, M. Albers, S. Almaraz-Calderon, B. Bucher, M.P. Carpenter, C.J. Chiara, D. Cline, H.L. Crawford, H.M. David, J. Harker, A.B. Hayes, C.R. Hoffman, B.P. Kay, K. Kolos, A. Korichi, T. Lauritsen, A.O. Macchiavelli, A. Richard, D. Seweryniak, A. Wiens   +24 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Disentangling the nuclear shape coexistence in even-even Hg isotopes using the interacting boson model

EPJ Web of Conferences, 2015
We intend to provide a consistent description of the even-even Hg isotopes, 172–200Hg, using the interacting boson model including configuration mixing. We pay special attention to the description of the shape of the nuclei and to its connection with the
García-Ramos J.E., Heyde K.
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source