Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The neural mechanisms of reliability weighted integration of shape information from vision and touch
Helbig HB, Ernst MO, Ricciardi E, et al. The neural mechanisms of reliability weighted integration of shape information from vision and touch. NeuroImage. 2011;60(2):1063-1072.Behaviourally, humans have been shown to integrate multisensory information in
Pietrini, Pietro +31 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Analyzing the Response Behavior of Lumbriculus variegatus (Oligochaeta: Lumbriculidae) to Different Concentrations of Copper Sulfate Based on Line Body Shape Detection and a Recurrent Self-Organizing Map. [PDF]
Ji CW +5 more
europepmc +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Voxel-space shape grammars [PDF]
The field of Procedural Generation is being increasingly used in modern content generation for its ability to significantly decrease the cost and time involved.
Crumley, Zacharia, Crumley, Mr. Zacharia
core
AUTO GMM-SAMT: An Automatic Object Tracking System for Video Surveillance in Traffic Scenarios
A complete video surveillance system for automatically tracking shape and position of objects in traffic scenarios is presented. The system, called Auto GMM-SAMT, consists of a detection and a tracking unit.
Quast Katharina, Kaup André
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A novel technique for reducing false positive detections in CAD-CTC [PDF]
Computed tomography colonoscopy (CTC) is an emerging alternative to conventional colonoscopy for colorectal cancer screening. A series of computer assisted diagnosis (CAD) techniques have been developed for use in CTC.
Sadleir, Robert J.T.
core

