Results 121 to 130 of about 37,716 (299)

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Generative design recommendations for the historical Mardiṅ High School and Gaziṗaşa Primary School buildings, Turkey

Conservation Science in Cultural Heritage
The genetic algorithm (GA) is inspired by natural selection, emphasizing the survival of the fittest. In GAs, data is encoded as genes, and optimal solutions are achieved through crossover and mutation operations on these genes.
Mizgin Gökçe Salık, Fatma Demet Aykal
doaj   +1 more source

Shaping the Grammar of Security.

AmeriQuests, 2014
In Australia, practices of preemptive deterrence construct the political identity of asylum seekers as the ‘illegal other’, and as a threat to national security and to national identity. At the core of the state's illegality regimes lies the endorsement of exclusionary norms through the grammar of security.
openaire   +1 more source

Highly Robust Sn‐Based MAX Anodes Constructed via Ti6C Octahedral Outer Immobilization and A‐Layer Fe Inner Anchoring for Long‐Life Lithium‐Ion Batteries

Advanced Science, EarlyView.
How can Sn‐based anodes achieve high capacity and long‐life cycling? This work unlocks the potential anode structure by confining Sn in the A layer of MAX phase with Ti6C octahedra as outer immobilization and Fe as inner anchors. The introduction of Fe dramatically strengthens the Ti–Sn bond to enhance structural integrity, modulate interfacial ...
Yu‐ang Lei, Yuchen Guo, Linkai He, Yi Tang, Junhui Zou, Yangyang Xie, Xiaodie Xuan, Zhao Bi, Yu Wang, Ting Liu, Yunqing Kang, Taotao Ai, Yusuke Yamauchi, Chenhui Yang   +13 more
wiley   +1 more source

A Digital Analysis of the “L”-Shaped Tujia Dwellings in Southeast Chongqing Based on Shape Grammar

Buildings
The Tujia ethnic group is one of the major ethnic groups in China, with a long history and abundant cultural heritage. As a distinctive architectural style, Tujia dwellings have evolved over thousands of years, developing a wealth of construction ...
Quan Wen, Yuqi Zhao, Xianwen Huang, Gang Wang   +3 more
doaj   +1 more source