Results 41 to 50 of about 1,006,629 (202)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Event shapes in e+e- annihilation and deep inelastic scattering

, 2003
This article reviews the status of event-shape studies in e+e- annihilation and DIS. It includes discussions of perturbative calculations, of various approaches to modelling hadronisation and of comparisons to data.Comment: Invited topical review for J ...
, Abbiendi G (OPAL Collaboration), Abe K (SLD Collaboration), Abreu P (DELPHI Collaboration), Abreu P (DELPHI Collaboration), Abreu P (DELPHI Collaboration), Abreu P (DELPHI Collaboration), Ackerstaff K (OPAL Collaboration), Acton P D (OPAL Collaboration), Acton P D (OPAL Collaboration), Adeva B (L3 Collaboration), Adloff C (H1 Collaboration), ALEPH Collaboration, Alexander G (OPAL Collaboration), Antonelli V, Appleby R B, Appleby R B, Appleby R B Salam G P, Bambade P Coster M J Fuster J Tortosa P, Banerjee S, Banfi A, Banfi A, Banfi A, Banfi A, Banfi A, Banfi A, Banfi A, Banfi A, Banfi A Salam G P Zanderighi G, Banfi A Salam G P Zanderighi G, Barate R (ALEPH Collaboration), Barclay D T, Bartel W (JADE Collaboration), Basham C L, Bauer C W Lee C Manohar A V Wise M B, Behrend H J (CELLO Collaboration), Bender D (HRS Collaboration), Berger C (PLUTO Collaboration), Berger C F, Berger C F, Berger C F, Bertram I A, Bethke S (Mark II Collaboration), Bigi I I Y, Bjorken J D, Braunschweig W (TASSO Collaboration), Braunschweig W (TASSO Collaboration), Brodsky S J, Burby S J, Buskulic D (ALEPH Collaboration), Buskulic D (ALEPH Collaboration), Campbell J M, Catani S, Corcella G, Dasgupta M, Dasgupta M, Dasgupta M, Dasgupta M, Dasgupta M, Dasgupta M, Dhar A, Dikeman R D, Dixon L J, Dokshitzer Y L, Dokshitzer Y L, Dokshitzer Y L, Dokshitzer Y L, Dokshitzer Y L, Dokshitzer Y L, Dokshitzer Y L, Donoghue J F, Ellis R K, Feynman R P, Feynman R P, Frixione S, Frixione S, Gardi E, Gardi E, Gardi E, Gavin P Salam, Gehrmann T, Giele W T, Gieseke S Ribon A Seymour M H Stephens P Webber B, Graudenz D, Gribov L V, Gribov L V, Grozin A G, Grunberg G, Hagiwara K (Particle Data Group Collaboration), Heister A (ALEPH Collaboration), Jones R W L, Kluge T, Kluth S, Kluth S Blumenstengel M Movilla Fernandez P A Bethke S Biebel O Pahl C Schieck J (JADE Collaboration), Knowles I G, Korchemsky G P, Korchemsky G P, Korchemsky G P, Korchemsky G P Sterman G, Krauss F, Li Y K (AMY Collaborationy), Magnea L, Martyn H U (H1 Collaboration), McCance G J, Movilla Fernandez P A, Movilla Fernandez P A, Mrinal Dasgupta, Nagy Z, Nagy Z, Nagy Z, Nason P, Neubert M, Neubert M, Petersen A (Mark II Collaboration), Pfeifenschneider P (JADE Collaboration), Pukhov A, Salam G P, Salam G P Trócsányi Z, Schieck J (for the OPAL Collaboration), Sjöstrand T Eden P Friberg C Lönnblad L Miu G Mrenna S Norrbin E, Smye G E, Stenzel H, Stevenson P M, Streng K H, Trocsanyi Z, Webber B R, Webber B R, Webber B R, Weigert H, Weinzierl S, Yuasa F, Zanderighi G   +131 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Shape invariant modelling pricing kernels and risk aversion [PDF]

Pricing kernels play a major role in quantifying risk aversion and investors' preferences. Several empirical studies reported that pricing kernels exhibit a common pattern across dierent markets.
Juhyun Park, Maria Grith, Wolfgang Härdle   +2 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Improved Algorithms for Radar-based Reconstruction of Asteroid Shapes

, 2015
We describe our implementation of a global-parameter optimizer and Square Root Information Filter (SRIF) into the asteroid-modelling software SHAPE.
Greenberg, Adam H., Margot, Jean-Luc
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source