ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Shape Optimization and Experimental Investigation of Glue-Laminated Timber Beams. [PDF]
Szeptyński P, Jasińska D, Mikulski L.
europepmc +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Adjoint-Assisted Shape Optimization of Microlenses for CMOS Image Sensors. [PDF]
Arfin R +3 more
europepmc +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Shape optimization of a rubber bumper by using Ansys optiSlang
This thesis aimed to explore the application of optimization algorithms, through the shape optimization of a rubber bumper, a crucial component in automotive engineering.
Platonov, Iurii
core
Inverse Design of Multi-Port Power Splitter with Arbitrary Ratio Based on Shape Optimization. [PDF]
Liu Y +6 more
europepmc +1 more source
Dosimetric comparison of dynamic conformal arc integrated with segment shape optimization and variable dose rate versus volumetric modulated arc therapy for liver SBRT. [PDF]
Thaper D +6 more
europepmc +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Significance of Inverse Planning With Variable Dose Rate and the Segment Shape Optimization in Dynamic Conformal Arcs Using the High-Definition Dynamic Radiosurgery Platform for Single Brain Metastases. [PDF]
Ohtakara K, Suzuki K.
europepmc +1 more source

