Results 81 to 90 of about 3,793,481 (295)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Recovery capital pathways : modelling the components of recovery wellbeing. [PDF]

, 2017
In recent years, there has been recognition that recovery is a journey that involves the growth of recovery capital. Thus, recovery capital has become a commonly used term in addiction treatment and research yet its operationalization and measurement has
David Best, Lehman, John, Best, David, Edwards, Michael, Ivan Cano, John Lehman, Cano, Ivan, Michael Edwards   +7 more
core   +1 more source

Facile design of heat-triggered shape memory ethylene-acrylic acid copolymer/chloroprene rubber thermoplastic vulcanizates

eXPRESS Polymer Letters, 2020
Stimuli-responsive shape-memory ethylene-acrylic acid copolymer (EAA)/chloroprene rubber (CR) thermoplastic vulcanizates (TPVs) were prepared via dynamic vulcanization.
F. F. Liu, Y. T. Sun, Z. B. Wang
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Findings from Transforming Youth Recovery’s 2017 Recovery Census [PDF]

, 2018
In 2013, Transforming Youth Recovery (TYR) published the 38 Assets for Building Collegiate Recovery Capacity as a guide for its early stage grant program, Seeds of Hope.
Jones, Erin K
core   +1 more source

Experimental Evaluation of Mechanical Properties, Thermal Analysis, Morphology, Printability, and Shape Memory Performance of the Novel 3D Printed PETG‐EVA Blends

Macromolecular Materials and Engineering
Polyethylene terephthalate glycol (PETG) is a novel amorphous shape memory polymer with excellent printability for 4D printing. In this article, ethylene‐vinyl acetate (EVA) is used as a biocompatible and non‐toxic copolymer to improve plasticity and ...
Saeed J. A. Ali, Davood Rahmatabadi, Mostafa Baghani, Majid Baniassadi   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Building Capacity for Recovery Support at Institutions of Higher Education [PDF]

, 2018
Capacitype™ data and mapping services help groups and organizations build capacity for recovery in their communities. The simple idea behind Capacitype is to invite everyone to go out and map assets – those people, places, and services that people are ...
Hart, Christopher D
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source