Results 101 to 110 of about 1,663,306 (288)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Shape transformation using variational implicit functions

Proceedings of the 26th annual conference on Computer graphics and interactive techniques - SIGGRAPH '99, 1999
Traditionally, shape transformation using implicit functions is performed in two distinct steps: 1) creating two implicit functions, and 2) interpolating between these two functions. We present a new shape transformation method that combines these two tasks into a single step. We create a transformation between two N-dimensional objects by casting this
Turk, Greg, O'Brien, James F
openaire   +6 more sources

Shape transformation transitions of a tethered surface model

, 2007
A surface model of Nambu and Goto is studied statistical mechanically by using the canonical Monte Carlo simulation technique on a spherical meshwork.
Akiyoshi, Ambjorn, Ambjorn, Baumgartner, Bowick, Bowick, Bowick, Catterall, David, Dobereiner, Endo, Evans, Grest, H. Koibuchi, Helfer, Helfrich, Hotani, Jaric, Kantor, Kleinert, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Kownacki, Paczuski, Peliti, Polyakov, Pott, Seifert   +32 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Study the effects of residual B19' phase on the phase transformation in shape memory NiTi alloys fabricated by laser powder bed fusion

Journal of Materials Research and Technology
The shape memory effect of near-equiatomic Ni–Ti shape memory alloys (SMAs) fabricated via laser powder bed fusion (LPBF) is attributed to the diffusionless phase transformation between austenite (B2) and martensite (B19').
Shenyue Zhou, Yue Wu, Yunlai Deng, Xiaobin Guo, Wei Jiang   +4 more
doaj   +1 more source

Curvature by design and on demand in liquid crystal elastomers

, 2017
The shape of liquid crystalline elastomers (LCEs) with spatial variation in the director orientation can be transformed by exposure to a stimulus. Here, informed by previously reported analytical treatments, we prepare complex spiral patterns imprinted ...
Godman, Nicholas P., Kowalski, Benjamin A., Mostajeran, Cyrus, Warner, Mark, White, Timothy J.   +4 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conditional Transformation Models

, 2012
The ultimate goal of regression analysis is to obtain information about the conditional distribution of a response given a set of explanatory variables.
Bühlmann, Bühlmann, Bühlmann, Bühlmann, Chen, Chen, Cheng, Cheng, Currie, Dette, Doksum, Eilers, Fenske, Friedman, Gilchrist, Gneiting, Gneiting, Gneiting, Hall, Hall, Hayfield, He, Hofner, Hothorn, Koenker, Koenker, Koenker, Kriegler, Li, Lu, Lu, Mayr, Ridgeway, Rigby, Schemper, Schild, Schmid, Schnabel, Sexton, Shen, Tutz, Tutz, van de Geer, Wu, Zeng, Zheng   +45 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source