Results 111 to 120 of about 1,675,077 (286)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Numerical Model For Vibration Damping Resulting From the First Order Phase Transformations

open access: yes, 2007
A numerical model is constructed for modelling macroscale damping effects induced by the first order martensite phase transformations in a shape memory alloy rod.
Melnik, Roderick V. N.   +1 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Supporting reinterpretation in computer-aided conceptual design [PDF]

open access: yes, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder)   +7 more
core  

FtsZ‐Induced Shape Transformation of Coacervates

open access: yesAdvanced Biosystems, 2018
AbstractRecently, both the cellular and synthetic biology communities have expressed a strong interest in coacervates, membrane‐less liquid droplets composed of densely packed multivalent molecules that form as a result of spontaneous phase separation.
Federico Fanalista   +4 more
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Implementation of the harmonic transformation method in shape optimization

open access: yesComputer Assisted Methods in Engineering and Science, 2023
The paper describes an implementation of the variant of the speed method in shape optimization for plane elastic structures, based on harmonic transformations.
Antoni Żochowski
doaj  

Learning shape-to-shape transformation

open access: yes, 2020
Many problems in computer graphics and geometric modeling, e.g., skeletonization, surface completion, and shape style transfer, can be posed as a problem of shape-to-shape transformation. In this thesis, we are interested in learning general-purpose shape transform, e.g., between 3D objects and their skeletons, between chairs and tables, and between ...
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An efficient experimental approach for high-throughput discovery of novel Ti-based shape-memory alloys

open access: yesJournal of Materials Research and Technology
β-Ti shape-memory alloys, that show shape-memory effect or superelasticity owing to thermoelastic martensitic transformation, have potential for various applications.
Yuxin Song   +3 more
doaj   +1 more source

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