Results 131 to 140 of about 4,022,812 (293)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Magnetic shape-memory alloys: thermomechanical modelling and analysis

, 2014
A phenomenological model for the coupled thermo-electro-magneto-mechanical and phase-transformation behaviour of magnetic shape-memory alloys is advanced in small strains and eddy current approximation.
U Stefanelli, T Roubicek
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Shape Machine and Architecture Theory

, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 11:30 a.m. in theJohn & Joyce Caddell Building, Flex Space.Heather Ligler is an architect and design researcher interested in how generative and parametric design both provide a new ...
Ligler, Heather
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Kurtosis transformation and kurtosis ordering [PDF]

Leptokurtic distributions can be generated by applying certain non-linear transformations to a standard normal random variable. Within this work we derive general conditions for these transformations which guarantee that the generated distributions are ...
Fischer, Matthias J., Klein, Ingo
core  

Nonspherical Liquid Crystalline Assemblies with Programmable Shape Transformation

, 2018
Liquid crystalline (LC) assemblies with tailored shape and programmable shape transformation were prepared via polymerization-induced self-assembly. The influence of polymerization temperature and solvent on the shape of the LC assemblies indicated that ...
Yen Wei (1396648), Jinying Yuan (2285431), Jun Zhang, Jun Zhang (48506), Meng Huo (3161172), Meng Huo, Guangjie Song (5522210), Jinying Yuan, Guangjie Song, Yen Wei   +9 more
core   +1 more source

Phages Shape the Transformation of Organic Matter During Composting

Microbial Biotechnology
Microorganisms drive the biotransformation of dissolved organic matter (DOM) during organic wastes composting, yet the role of phages with different lifestyles (i.e., temperate and virulent) in this process remains poorly understood.
Yuanyuan Bao, Jan Dolfing, Ruirui Chen, Chongwen Qiu, Jianwei Zhang, Xin Zhou, Liang Liu, Yiming Wang, Xiangui Lin, Youzhi Feng   +9 more
doaj   +1 more source