Results 101 to 110 of about 94,692 (282)

ACKR1/Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Clozapine is licenced for treatment‐resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis.
Stephen Murtough, Oriella Stellakis, Daisy Mills, Blanca Bjourson, Vicky Chaplin, Dharmisha Chauhan, Bev Chipp, Marius Cotic, Jana de Villiers, Olubanké Dzahini, Frances Elmslie, Katie Evans, Shreyans Gandhi, Dyfrig A. Hughes, Huajie Jin, Daniele Panconesi, Anna Skowronska, Sanjay M. Sisodiya, Ed Silva, Vicky Stinton, Sara Stuart‐Smith, Sarah Tarrant, David Taylor, Lauren Varney, James T. R. Walters, Michelle Wood, Jessica Woodley, Cinzia Dello Russo, Munir Pirmohamed, Elvira Bramon   +29 more
wiley   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Plasma Metabolite Profiles in First Episode Psychosis: Exploring Symptoms Heterogeneity/Severity in Schizophrenia and Bipolar Disorder Cohorts

Frontiers in Psychiatry, 2020
IntroductionThe first symptoms of psychosis are frequently shared amongst several neuropsychiatry disorders, which makes the differentiation by clinical diagnosis challenging.
Helena P. G. Joaquim, Helena P. G. Joaquim, Helena P. G. Joaquim, Alana C. Costa, Alana C. Costa, Leda L. Talib, Leda L. Talib, Frederik Dethloff, Mauricio H. Serpa, Mauricio H. Serpa, Marcus V. Zanetti, Marcus V. Zanetti, Martinus van de Bilt, Martinus van de Bilt, Christoph W. Turck   +14 more
doaj   +1 more source

Residual negative symptoms differentiate cognitive performance in clinically stable patients with schizophrenia and bipolar disorder [PDF]

, 2014
Cognitive deficits in various domains have been shown in patients with bipolar disorder and schizophrenia. The purpose of the present study was to examine if residual psychopathology explained the difference in cognitive function between clinically ...
Krishnadas, Rajeev, Moore, Brian, Nayak, Ajita, Ramanathan, Seethalakshmi, Wong, Eugene   +4 more
core   +4 more sources

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Metacognition in schizophrenia disorders: Comparisons with community controls and bipolar disorder: Replication with a Spanish language Chilean sample [PDF]

, 2018
Metacognition refers to the activities which allow for the availability of a sense of oneself and others in the moment. Research mostly in North America with English-speaking samples has suggested that metacognitive deficits are present in schizophrenia ...
Armijo, Ivan, Ballerini, Massimo, Gagen, Emily C., Irarrázaval, Leonor, Lysaker, Paul H., Mancini, Milena, Stanghellini, Giovanni   +6 more
core   +1 more source

Latent Trajectories of Body Mass Index and Depressive Symptoms in Inpatients With Anorexia Nervosa: Predictors and Outcomes

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Inpatient treatment aimed at weight restoration and psychiatric stabilization is often required for individuals with anorexia nervosa (AN). This study aimed to identify distinct trajectories of change in body mass index (BMI) and depressive symptoms during inpatient treatment, examine clinical predictors and outcomes, and test ...
Matteo Martini, Mie Sedoc Jørgensen, Cristiano Dani, Anne Bryde Christensen, Magnus Sjögren, Nadia Micali   +5 more
wiley   +1 more source

Co‐Producing the Transition to Eating Disorder Youth Intervention: Experience‐Based Co‐Design Workshops Supporting Young People in Transition

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are severe and complex psychiatric illnesses, with adolescence and young adulthood representing particularly vulnerable periods for onset, relapse and disruptions in treatment. The transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) is especially complex ...
Maria Livanou, Marta Marlais, Charlotte Burton, Nora Kornai, Anna Bromley, Pareena Dutt, Jiarui Li, Tiffany Luxford, Francesca Marshall, Maria Georgia Dioletta, Molly Henson, Jun Teh, Emily Nuttall, Ashish Kumar, Kevin Christian, Carolyn Hatton, Zara Smalley, Grace Hill, Anya Heneghan, Kat Novogrudsky   +19 more
wiley   +1 more source

“Dem sey mi mad”: a scoping review of the attitudes and beliefs of English-speaking Afro-Caribbeans about psychosis

Frontiers in Psychiatry
IntroductionThe mental health disparities suffered by the English-speaking Afro-Caribbean diaspora living with psychosis in North America and the United Kingdom have been well described for decades, but the root causes of these disparities remain poorly ...
Sommer Knight, Xin Qiang Yang, G. Eric Jarvis, G. Eric Jarvis, G. Eric Jarvis   +4 more
doaj   +1 more source