Results 81 to 90 of about 7,267 (190)
Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan +11 more
wiley +1 more source
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich +21 more
wiley +1 more source
Ultrafast Time-and-Space- Domain Holography by Spectral Hole Burning in Dye-Doped Polymers
Certain photochromic materials exhibit at liquid-helium temperature a special property of very high selectivity in frequency dimension. This phenomenon, commonly known as spectral hole burning (SHB), makes it possible to extend conventional ...
Aleksander Rebane
doaj +2 more sources
The small hive beetle (SHB) was first detected in Italy in 2014 and remains confined to the regions of Calabria and Sicily (Italy). The environmental and colony-related factors favorable to the development of SHBs are widely studied, but mainly at the ...
Camilla Di Ruggiero +7 more
doaj +1 more source
Abstract Bacterial wilt, caused by Ralstonia spp., poses a major threat to blueberry (Vaccinium corymbosum) production due to its persistence and rapid spread through soil and infected stock, highlighting the need for genetic insights to guide breeding strategies. This study investigated the genetic basis of bacterial wilt resistance in blueberry using
Lushan Ghimire +7 more
wiley +1 more source
Building healthier hearts: 5 year action plan 2000-2004 (6.36 MB) [PDF]
SHB ...
Southern Health Board (SHB)
core
GmDOF3.1‐GmCPX Module Regulates Nodulation and Nitrogen Fixation Abilities in Soybean
ABSTRACT Soybean nodule nitrogen fixation is very important, which can provide a large amount of nitrogen supply for its own growth and that of other crops, but the mechanism is largely unclear. In the present study, a coproporphyrinogen oxidase gene, GmCPX, was identified to facilitate soybean nodulation and nitrogen‐fixation under the regulation of ...
Xinzhu Xing +10 more
wiley +1 more source

