Results 161 to 170 of about 18,650 (200)

SHBG Gene Polymorphisms and Their Influence on Serum SHBG, Total and Free Testosterone Concentrations in Men

Journal of Clinical Endocrinology and Metabolism
Abstract Context Genetic variation in SHBG structure may affect estimates of sex steroid exposure by altering the affinity of the protein for its ligand. Consequently, free hormone calculations assuming constant binding affinity may, for certain genetic variations, lead to incorrect diagnoses if ...
Leen Antonio, Bruno Lapauw, Ido Kema
exaly   +4 more sources

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Changes in the shbg concentration during danazol treatment

Acta Obstetricia Et Gynecologica Scandinavica, 1984
Abstract. Serum levels of sex hormone binding globulin (SHBG) were measured by radioelectro‐immunoassay before and during administration of danazol in daily doses varying between 200 and 800 mg for a period of 1–6 months. The patients consisted of different groups of regularly menstruating women (n = 76) and of postmenopausal women (n = 12).
S Gershagen, G Rannevik
exaly   +3 more sources

SHBG and endothelial function in older subjects

International Journal of Cardiology, 2013
Endothelial dysfunction is predictor of cardiovascular diseases that have different prevalence in men and women before menopause. Sex hormones and sex hormone binding globulin (SHBG), novel risk factors for diabetes and cardiovascular diseases even in older individuals, might explain this difference. However, the relationship between these hormones and
Riccardo Volpi, Marcello Maggio, Fulvio Lauretani   +2 more
exaly   +7 more sources

Dimerization of shbg by gelatin and dithiothreitol. Implications for the measurement of SHBG binding capacity in human serum

Journal of Steroid Biochemistry, 1987
In individual serum samples, the sex hormone-binding globulin (SHBG) binding capacity for dihydrotestosterone (DHT) was systematically found to be decreased by 30-60% when either gelatin or dithiothreitol (DTT) was present in the assay buffer. The presence of gelatin in the buffer prevented DTT from further decreasing the SHBG binding capacity of serum
P, Englebienne, P, Van Hoorde, R, Verheyden   +2 more
openaire   +2 more sources

Complex structure and regulation of the ABP/SHBG gene

The Journal of Steroid Biochemistry and Molecular Biology, 1991
Extracellular androgen-binding proteins (ABPs) are thought to modulate the regulatory functions of androgens and the trans-acting nuclear androgen receptor. Testicular ABP and plasma sex hormone-binding globulin (SHBG), which is produced in the liver, are encoded by the same gene.
D R, Joseph, P M, Sullivan, Y M, Wang, D E, Millhorn, D M, Bayliss   +4 more
openaire   +2 more sources

Novel insights in SHBG regulation and clinical implications

Trends in Endocrinology & Metabolism, 2015
Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause for low SHBG levels found in obesity.
Rafael, Simó, Cristina, Sáez-López, Anna, Barbosa-Desongles, Cristina, Hernández, David M, Selva   +4 more
openaire   +2 more sources

Testosterone, Shbg and Albumin in Patients with Ovarian Carcinoma

Acta Obstetricia et Gynecologica Scandinavica, 1986
Plasma testosterone, unbound testosterone, Sex Hormone Binding Globulin (SHBG) and albumin were studied in women with “non‐endocrine” ovarian carcinoma prior to and during chemotherapy. Fifty‐one postmenopausal or oophorectomized women with cancer of the ovary were studied. the histologic types were IC, IIC, IIIC, V and FIGO stages I–IV.
C G, Mählck, K, Grankvist, T, Bäckström, O, Kjellgren   +3 more
openaire   +2 more sources

Roles of estrogen and SHBG in prostate physiology

The Prostate, 1996
Heretofore, the function of estrogen in the prostate, other than as an antiandrogen, has been unclear. In this review of a growing fund of knowledge about both estrogen and the plasma protein, sex hormone-binding globulin (SHBG), or testosterone-estradiol binding globulin (TeBG), the hypothesis is proposed that estrogen, mediated by SHBG, participates ...
openaire   +2 more sources

Association of pentanucleotide polymorphism in SHBG gene with serum SHBG levels and cardiovascular risk factors in women with PCOS

Molecular Medicine Reports, 2015
Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder in women of reproductive age. The aim of this study was to evaluate the influence of TAAAA repeat allele length on serum SHBG levels and on cardiovascular risk factors in PCOS patients.
Pavičić Baldani, Dinka, Škrgatić, Lana, Černe, Jasmina Živa, Kralik Oguić, Saša, Geršak, Blaž Matija, Geršak, Ksenija   +5 more
openaire   +2 more sources

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

Annals of Nutrition and Metabolism, 2015
<b><i>Background:</i></b> Decreased sex hormone-binding globulin (SHBG) levels were associated with polycystic ovary syndrome (PCOS). <i>SHBG</i> polymorphisms associated with reduced SHBG production were tested for their association with PCOS, but with inconclusive results. We tested whether altered SHBG levels and &
Tala M, Abu-Hijleh, Emily, Gammoh, Amna S, Al-Busaidi, Zainab H, Malalla, Samira, Madan, Naeema, Mahmood, Wassim Y, Almawi   +6 more
openaire   +2 more sources