Results 51 to 60 of about 47,158 (302)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The primary influence of shear band evolution on the slope bearing capacity
Journal of Rock Mechanics and Geotechnical Engineering, 2023 Slope bearing capacity is one of the most important characteristics in slope engineering and is strongly influenced by weak planes, loading conditions, and slope geometry.
Lanting Wei +3 more
doaj +1 more source
Shear-banding instability in arbitrarily inelastic granular shear flows [PDF]
Physical Review E, 2019 One prototypical instability in granular flows is the shear-banding instability, in which a uniform granular shear flow breaks into alternating bands of dense and dilute clusters of particles having low and high shear (shear stress or shear rate), respectively.
Priyanka Shukla +2 more
openaire +3 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Minimal model for chaotic shear banding in shear thickening fluids [PDF]
Physical Review E, 2006 Revised version (in particular, new section III.E. and Appendix A)
Aradian, A., Cates, M. E.
openaire +3 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
ModellingThe initiation condition of the shear band in gas hydrate-bearing sediment (GHBS) was analyzed in this study. First, the mathematical model considering the pore diffusion and stress conservation equations was constructed.
Yudong Huang +6 more
doaj +1 more source
Grain-subdivision-dominated microstructure evolution in shear bands at high rates
Materials Research Letters, 2020 Shear banding is an important deformation and failure mechanism in metallic systems, especially at high-rate straining. Dynamic recrystallization was often reported to account for the refined microstructure of shear bands but rarely confirmed using ...
Xiaolong Ma +4 more
doaj +1 more source
Metals, 2023 Shear localization is one of the most important failure mechanisms subjected to high-strain-rate deformation and has significant effects on the process, plastic deformation, and catastrophic failure of a material.
Ming-Yao Su +5 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source