Results 31 to 40 of about 99,624 (259)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Research Progress on Shear Characteristics and Rapid Post-Disaster Construction of Narrow-Width Steel Box–UHPC Composite Beams

Buildings
The narrow-width steel box girder is an important type of steel–concrete composite bridge structure, which is usually composed of reinforced concrete wing plates, narrow steel boxes partially injected with concrete, and shear connectors that promote ...
Yunteng Chen, Jiawei Xu, Peilong Yuan, Qiang Wang, Guanhua Cui, Xulin Su   +5 more
doaj   +1 more source

Calculation of Shear Capacity of Plastic Hinge Zone of Hydraulic Reinforced Concrete Column

工程科学与技术, 2022
In view of the flexural-shear failure of the plastic hinge zone of hydraulic reinforced concrete (RC) columns during earthquake, the shear capacity of the plastic hinge zone of hydraulic RC columns was studied.
Ying MA, Mengdie LI, Zhiguo SUN, Zebin WU   +3 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

Advanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo, Shuo Qu, Shiming Gao, Xu Song   +3 more
wiley   +1 more source

Experimental Study on the Shear Behavior of HTRCS-Reinforced Concrete Beams

Buildings
High-toughness resin concrete steel mesh (HTRCS) composites, as a novel reinforcement material, are extensively employed, yet there has been a lack of comprehensive quantitative studies on them, and our knowledge about them predominantly relies on ...
Qu Yu, Yongqing Yang, Qisong Lin, Dan Yang   +3 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Shear Capacity and Failure Behavior of Steel-Reinforced High Ductile Concrete Beams

Advances in Materials Science and Engineering, 2015
The shear behavior of six high ductile fiber reinforced concrete (HDC) beams is studied to investigate the influence of shear-span ratio and HDC mechanical property on the improvement of the shear failure mode and shear capacity of short beams.
Mingke Deng, Jie Dai, Huasong Lu, Xingwen Liang   +3 more
doaj   +1 more source