Results 201 to 210 of about 22,047 (242)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Research on numerical simulation of surrounding rock stability of deep roadway with advanced strain softening model based on Hoek-Brown criterion. [PDF]

Sci Rep
Wang R, Wu R, Xu J, Wu H, Wang K.
europepmc   +1 more source

Bridged h‐BN Nanosheets Coatings: Simultaneous Shielding Atomic‐Oxygen Irradiation and Achieving Superior Friction Performance

Advanced Science, EarlyView.
ABSTRACT To confront extreme space environments, a combination of inorganic and organic coatings can provide a pathway for offering highly durable radiation resistance and anti‐friction simultaneously. Herein, a strong interfacial 3D hydrogen‐bonding network is designed to create robust hexagonal boron nitride (h‐BN) based polymer coatings with ...
Zhuoyi Li, Changning Bai, Xingkai Zhang, Yusheng Liang, Wei Wu, Dingrui Zhou, Tao Du, Chunjin Wang   +7 more
wiley   +1 more source

Pre- and Post-Interventional Hemodynamic Characterization of the Femoropopliteal Artery Using Vector Flow Imaging in Peripheral Arterial Occlusive Disease. [PDF]

J Ultrasound Med
Prüser JL, Winkelbauer G, Dieker W, Adler A, Amendt K, Sigl M.   +5 more
europepmc   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear-induced Death During Hematogenous Dissemination. [PDF]

Adv Sci (Weinh)
Zhang C, Wang Q, Li K, Hu G, Xin Y, Tang K, Hu B, Du P, Mao R, Ji B, Tan Y.   +10 more
europepmc   +1 more source

Er YAG laser debonding of zirconia restorations from titanium abutments depends on cement type water content and thickness. [PDF]

Sci Rep
Chen R, Chen Y, Jiang X, Zheng Z, Lin J.
europepmc   +1 more source

Endothelial senescence of the vertebral artery in the context of cervical degeneration: biomechanically driven remodeling of the hemodynamic environment. [PDF]

Front Cell Dev Biol
Wang X, Liu X, Yu L, Xue Y, Hu K, Song Y, Song M.   +6 more
europepmc   +1 more source

The free vibrational characteristic of PFGM beams near the post-buckling configuration under thermal loads. [PDF]

Sci Prog
Lyu Q, Zhao Y, Zeng H, Mu Y.
europepmc   +1 more source

Analysis of the influence of nonlocal factors on the vibration of Rayleigh nonlocal nanobeams on elastic foundations. [PDF]

Sci Rep
Zhao K, Wang G, Zhou Z, Wang L.
europepmc   +1 more source