Results 41 to 50 of about 566,845 (299)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimization the Resistance Spot Welding Parameters of Austenitic Stainless Steel and Aluminum Alloy Using Design of Experiment Method [PDF]

Engineering and Technology Journal, 2016
This research aims to study the effect of RSW parameters on the sheerforce of the spot weldedfor two materials {AISI 304L and AA 6061-T6}with (0.5 and 0.7 mm) thickness.
Sabah Khammass Hussein, Osamah Sabah Barrak   +1 more
doaj   +1 more source

Three-Dimensional Relativistic Magnetohydrodynamic Simulations of Current-Driven Instability with A Sub-Alfvenic Jet: Temporal Properties

, 2011
We have investigated the influence of a velocity shear surface on the linear and non-linear development of the CD kink instability of force-free helical magnetic equilibria in 3D.
Aloy, Anile, Antón, Appl, Bateman, Baty, Beckwith, Begelman, Blandford, Blandford, Bromberg, Carey, De Villiers, De Villiers, Georganopoulos, Gómez, Hardee, Hawley, Istomin, Istomin, Ken-Ichi Nishikawa, Lery, Lyubarsky, McKinney, Mizuno, Mizuno, Mizuno, Mizuno, Mizuno, Mészáros, Nakamura, Nakamura, Narayan, Ouyed, Philip E. Hardee, Weisskopf, Yosuke Mizuno   +36 more
core   +1 more source

Directional shear force microscopy

Applied Physics Letters, 2001
We describe a technique, based on shear force microscopy, that allows one to detect shear forces in a chosen direction at the nanometer scale. The lateral direction of an oscillating probe tip is determined by selecting which of the four quadrants are excited on the piezo driver.
Burns, A. R, Carpick, Robert W
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Shearing mechanical model and experimental verification of bolts in jointed rock mass

Yantu gongcheng xuebao, 2018
Based on the principle of the minimum residual energy, the relationship between the horizontal shear displacement of the joint surface and the axial and tangential deformation of the bolt is analyzed considering the shear deformation of the bolts in ...
LIU Quan-sheng 1, 2, LEI Guang-feng 1,3, , PENG Xing-xin 1, 3, WEI Lai 1, 3
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Study on Cutting Force of Machining In Situ TiB2 Particle-Reinforced 7050Al Alloy Matrix Composites

Metals, 2017
In situ TiB2 particle-reinforced 7050Al alloy matrix composites are a new category of particulate metal matrix composites with improved mechanical and physical properties.
Yifeng Xiong, Wenhu Wang, Ruisong Jiang, Kunyang Lin   +3 more
doaj   +1 more source

Generation of coherent magnetic fields in sheared inhomogeneous turbulence: No need for rotation? [PDF]

, 2011
Coherent magnetic fields are often believed to be generated by the combination of stretching by differential rotation and turbulent amplification of magnetic field, via the so-called alpha effect. The latter is known to exist in helical turbulence, which
Eun-jin Kim, Kichatinov L. L., Krause F., Moffatt H. K., Nicolas Leprovost   +4 more
core   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source