Results 41 to 50 of about 129,274 (296)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Research on Influence mechanism of composite interlaminar shear strength under normal stress

Science and Engineering of Composite Materials, 2020
The normal stress along the shear plane has great effect on the composite intralaminar shear strength. However, the influence mechanism on composite interlaminar shear strength under the normal stress along the shear plane was not truly reflected by the ...
Li Fei, Deng AnZhong, Zhao QiLin, Duan Jinhui   +3 more
doaj   +1 more source

Modification of linear regression method for rock shear strength parameters under triaxial condition

Rock and Soil Mechanics, 2022
The triaxial strength envelope of rocks is usually nonlinear, and the shear strength parameters obtained by the linear regression method (LRM) are highly sensitive to confining pressure.
LI Bin, WANG Da-guo, HE Zhi-liang, WANG Peng   +3 more
doaj   +1 more source

THE INVESTIGATION OF THE STRENGTH REDUCTION FACTOR IN PREDICTING THE SHEAR STRENGTH

Journal of Theoretical and Applied Mechanics, 2015
Design codes propose to restrict the nominal probability of failure within specific target structural reliability levels using a load factor and a strength reduction factor. In the current ACI318 Code, the strength reduction factor varies from 0.65 to 0.90, and the value considered in predicting the shear strength equals to 0.75.
Arslan, Guray, Sagiroglu, Ali, Noyan Alacali, Sema   +2 more
openaire   +5 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Derivation of the shear strength of continuous beams [PDF]

European Journal of Wood and Wood Products, 2010
The elastic--full plastic loading curve is for all materials sufficient to explain the strength of beams and beam columns loaded by bending and compression. This theory is extended for the influence of shear stress, and it is shown to be the only way to explain the combined bending-shear strength from test results. Also, the in the past derived bearing
van der Put, T.A.C.M. (author), van de Kuilen, J.W.G. (author)   +1 more
openaire   +4 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source