Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Experimental Investigation of Stress Relaxation Behavior in Sand and Sand-Geotextile Interface [PDF]
پژوهشهای زیرساختهای عمرانیIn this research, the phenomenon of stress relaxation in unreinforced and reinforced sandy soil with geotextile layer has been studied using a large-scale direct shear test.
Javad Ghaffari, Somayyeh Fazeli
doaj +1 more source
The influence of consolidation on shear test results [PDF]
, 1987 Measurements of the yield behaviour of a cohesive bulk solid in the Jenike shear tester are normally done in two steps. First, pre-shearing to a steady state yielding, and secondly, shearing under a lower normal stress to establish the shear stress at ...
Haaker, G.
core +2 more sources
Application of Friction Shear Test for Constitutive Modeling Evaluation of Magnesium Alloy AZ31B at high Temperature [PDF]
, 2020 The experimental determination of the flow stress and its mathematical formulation are essential for the numerical simulation of metal forming processes.
Gensch, Felix +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A machine learning-based method for predicting the shear behaviors of rock joints
Soils and FoundationsIn this study, machine learning prediction models (MLPMs), including artificial neural network (ANN), support vector regression (SVR), K-nearest neighbors (KNN), and random forest (RF) algorithms, were developed to predict the peak shear stress values ...
Liu He +4 more
doaj +1 more source
A thin rivulet or ridge subject to a uniform transverse\ud shear stress at its free surface due to an external airflow [PDF]
, 2012 We use the lubrication approximation to analyse three closely related problems involving a thin rivulet or ridge (i.e. a two-dimensional droplet) of fluid subject to a prescribed uniform transverse shear stress at its free surface due to an external ...
Duffy, B. R. +3 more
core
A Universal Criterion for Plastic Yielding of Metallic Glasses with a (T/Tg)2/3 Temperature Dependence [PDF]
, 2005 Room temperature (TR) elastic constants and compressive yield strengths of ~30 metallic glasses reveal an average shear limit gammaC=0.0267±0.0020, where tauY=gammaCG is the maximum resolved shear stress at yielding, and G the shear modulus.
Johnson, W. L., Samwer, K.
core +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Mechanical properties of a coiled tubing blowout preventer ram in the shearing process
Natural Gas Industry B, 2019 A shear ram is of great significance to ensuring the safe operation of oil/gas well drilling and production, but the mechanical properties of the ram itself in the shearing process are rarely researched.
Bing Liu +5 more
doaj +1 more source