Results 101 to 110 of about 1,162,244 (382)
Alternative ORFs and small ORFs: shedding light on the dark proteome.
Nucleic Acids Research, 2019 Traditional annotation of protein-encoding genes relied on assumptions, such as one open reading frame (ORF) encodes one protein and minimal lengths for translated proteins.
M. Orr +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
EVALUATION OF RECOMBINANT AVIAN INFLUENZA COMPARED TO INACTIVATED VACCINES TO INDUCE IMMUNE RESPONSE IN CHICKEN [PDF]
Arab Universities Journal of Agricultural Sciences, 2018 The present Avian Influenza epidemic in Egypt is consider one of the major problems facing the poultry field and caused by circulation of genetically and antigenetically diverse influenza H5N1 viruses.
Dalia Omar, K. El-Dougdoug, B. Othman
doaj +1 more source
The onset of unsteadiness of two-dimensional bodies falling or rising freely in a viscous fluid: a linear study [PDF]
, 2011 We consider the transition between the steady vertical path and the oscillatory path of two-dimensional bodies moving under the effect of buoyancy in a viscous fluid.
Assemat, Pauline +2 more
core +2 more sources
Environmental science and pollution research international, 2017 Microplastics in the environment are a subject of intense research as they pose a potential threat to marine organisms. Plastic fibers from textiles have been indicated as a major source of this type of contaminant, entering the oceans via wastewater and
Bethanie M. Carney Almroth +5 more
semanticscholar +1 more source
NKG2D and MICA/B shedding: a ‘tag game’ between NK cells and malignant cells
Clinical & Translational Immunology, 2020 Natural killer (NK) cells are innate lymphocytes with cytotoxic functions and recognise target cells with the NK group 2D (NKG2D) receptor. Tumor cells are marked for NK‐cell‐mediated destruction upon expression of MICA and MICB (MICA/B), which are NKG2D
Samantha Xing, Lucas Ferrari de Andrade
semanticscholar +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PERSONALIZED BASELINE RISK STRATIFICATION IN HOSPITALIZED ADULT PATIENTS WITH COVID-19: PATIENT-SIMILARITY-BASED DATA SCIENCE SHEDS SOME LIGHT [PDF]
, 2021 Natalia Lattanzio +13 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source