Results 111 to 120 of about 1,162,244 (382)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Varying Flavobacterium psychrophilum shedding dynamics in three bacterial coldwater disease-susceptible salmonid (Family Salmonidae) species

open access: yesMicrobiology Spectrum
Flavobacterium psychrophilum causes bacterial coldwater disease (BCWD) and is responsible for substantial losses in farm and hatchery-reared salmonids (Family Salmonidae). Although F. psychrophilum infects multiple economically important salmonids and is
Christopher Knupp   +2 more
doaj   +1 more source

Parametric optimization of the femoropopliteal artery stent design based on numerical analysis [PDF]

open access: yes, 2021
High-failure rates of Peripheral Arterial Disease (PAD) stenting were reported due to the inability of certain stent strut configuration to accommodate severe biomechanical environment of the Femoro-Popliteal Artery (FPA) such as bends, twists, and ...
Kareem, Ali Kamil
core  

Social shedding: Identification and health of men’s sheds users.

open access: yesHealth Psychology, 2015
Extant research has previously found several benefits of community Men's Sheds. Drawing on social identity theory, we examine the extent to which membership in Men's Sheds can influence the quality of life of Men's Sheds users.We surveyed 322 Men's Sheds users in Australia on 4 quality of life domains and their willingness to take health advice offered
Sean Ford, Brett Scholz, Vinh N. Lu
openaire   +3 more sources

Duration of SARS‐CoV‐2 RNA shedding and factors associated with prolonged viral shedding in patients with COVID‐19

open access: yesJournal of Medical Virology, 2020
To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 RNA shedding in patients with coronavirus disease 2019 (COVID‐19). A retrospective cohort of COVID‐19 patients admitted to a designated hospital in
Tong-Zeng Li   +12 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

open access: yesFEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh   +7 more
wiley   +1 more source

Investigation of cavitation and vapor shedding mechanisms in a Venturi nozzle

open access: yesThe Physics of Fluids, 2020
Cavitating flow dynamics are investigated in an axisymmetric converging–diverging Venturi nozzle. Computational Fluid Dynamics (CFD) results are compared with those from previous experiments.
Maxwell Brunhart   +6 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

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