Results 41 to 50 of about 225,470 (313)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe [PDF]

, 2010
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host.
González, L., E. Monleon, L. J. M. van Keulen, Jeffrey, M., Balkema-Buschmann, A., C. Hoffmann, Badiola, J.J., Lulini, B., Keulen, L.J.M., van, van Keulen, L.J.M., A. Balkema-Buschmann, Monleón, E., S. Siso, A. Ortiz-Pelaez, Langeveld, J.P.M., Hoffmann, C., J. J. Badiola, Sisó, S., Acín, C., Ortiz-Peláez, A., J. P. M. Langeveld, B. Iulini, M. Jeffrey, L. Gonzalez, C. Casalone, Casalone, C., C. Acin   +26 more
core   +1 more source

Chronic cardiomyopathy and encephalic spongy changes in sheep experimentally fed Ateleia glazioviana Miocardiopatia crônica e degeneração esponjosa do encéfalo em ovinos intoxicados experimentalmente por Ateleia glazioviana

Ciência Rural, 2006
Fifteen mature crossbred sheep were fed different daily amounts (2.5-35g kg-1 bw) of the fresh green leaves of Ateleia glazioviana for different periods of time (1-24 days). One sheep was not fed the plant and served as a control.
Margarida Buss Raffi, Raquel Rubia Rech, Elisa Simone Viegas Sallis, Aline Rodrigues, Claudio Severo Lombardo de Barros   +4 more
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Epidemiology of parasitic protozoan infections in Soay sheep (Ovis aries L.) on St Kilda [PDF]

, 2006
The feral Soay sheep (Ovis aries L.) population on Hirta, St Kilda, is host to a diverse component parasite community, but previous parasitological studies of the population have only focussed on the metazoan species.
B. H. CRAIG, L. E. B. KRUUK, Pilkington, J. G., Pemberton, J. M., Kruuk, L. E. B., J. M. PEMBERTON, J. G. PILKINGTON, Craig, B. H.   +7 more
core   +1 more source

Prevalence of chlamydiae in dairy cattle herds and factors contributing to the spread of infections

Journal of Veterinary Research
Different Chlamydia species affect cattle and contribute to economic losses. One of them, C. pecorum, is a globally endemic livestock pathogen. Despite its endemicity, prevalence data from Poland have so far been limited.
Szymańska-Czerwińska Mońika, Jodełko Agnieszka, Osiński Zbigniew, Zaręba-Marchewka Kinga, Niemczuk Krzysztof   +4 more
doaj   +1 more source

High frequency of cutaneous squamous cell carcinoma in Friesian Milchschaf sheep in Uruguay

Pesquisa Veterinária Brasileira, 2019
: This study described five cases of squamous cell carcinoma (SCC) in the pinnae, eyelids, and eyes of Friesian Milchschaf sheep from two flocks raised under extensive conditions in Uruguay.
Ricardo A. Costa, Carlos Schild, Dario Caffarena, Federico Giannitti, Georgett Banchero, Liliana DelPino, Franklin Riet-Correa   +6 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

The dynamic influence of the DRB1*1101 allele on the resistance of sheep to experimental Teladorsagia circumcincta infection [PDF]

, 2011
Suffolk sheep carrying the DRB1*1101 (previously referred to as-DRB1*0203 or G2) allele have been reported to show increased resistance to natural Teladorsagia circumcincta infection compared to non-carriers.
Sayers Gearoid, Barbara Good, Sayers, Gearoid, Good Barbara, Good, Barbara, Mulcahy, Grace, Sweeney, Torres, Mulcahy Grace, Hassan, Musa, Hanrahan, James P, Sweeney Torres, Grace Mulcahy, Musa Hassan, Hanrahan James P, James P Hanrahan, Hassan, Musa A., Campion, Deirdre P, Gearoid Sayers, Hassan Musa, Deirdre Campion, Hanrahan, James P., Torres Sweeney, Campion Deirdre, Campion, Deirdre   +23 more
core   +1 more source