Results 41 to 50 of about 172,493 (308)

Investigation of Strength and Buckling of Orthotropic Conical Shells and Conical Panels [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Математика. Механика. Информатика, 2020
In the construction, thin-walled shell structures are used to cover the buildings of large areas, such as stadiums, hangars, circuses, airports. In this paper, the strength and buckling of closed conical shells as well as their panels are studied.
Elena Olegovna Lapina   +1 more
doaj   +1 more source

Influence of Discretely Introduced Cutouts on the Buckling of Shallow Shells with Double Curvature [PDF]

open access: yesJournal of Applied and Computational Mechanics
The paper analyzes the influence of cutouts on the buckling of shallow shells with double curvature. Based on the Timoshenko-Reissner hypothesis, a mathematical model is presented that considers transverse shifts, material orthotropy, geometric ...
Nikolai Mishurenko, Alexey Semenov
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Walnut and Hazelnut Shells: Untapped Industrial Resources and Their Suitability in Lignocellulosic Composites

open access: yesApplied Sciences, 2020
Walnut and hazelnut shells are agricultural by-products, available in high quantities during the harvest season. The potential of using these two agricultural residues as raw materials in particleboard production has been evaluated in this study ...
Marius Cătălin Barbu   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Investigation of the accuracy and convergence of the results of thin shells analysis using the PRINS program

open access: yesStructural Mechanics of Engineering Constructions and Buildings, 2021
The theoretical foundations of compatible finite elements construction for static and dynamic analysis of single-layer and multilayer shells are discussed. These finite elements are implemented in the PRINS computer program.
Vladimir P. Agapov, Alexey S. Markovich
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

An analytical insight into the buckling paradox for circular cylindrical shells under axial and lateral loading [PDF]

open access: yes, 2015
A large number of authors in the past have concluded that the flow theory of plasticity tends to overestimate significantly the buckling load for many problems of plates and shells in the plastic range, while the deformation theory generally provides ...
GUARRACINO, FEDERICO   +5 more
core   +1 more source

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