Results 51 to 60 of about 203,990 (252)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Energy Assessment of Hazelnut Shells (Corylus avellana L.) of Selected Turkish Varieties

Energies
The purpose of this study was to evaluate the energy and environmental potential of waste biomass in the form of hazelnut shells from selected Turkish varieties of Corylus avellana L.
Kamila E. Klimek, Saban Kordali, Anna Borkowska, Ferah Yilmaz, Grzegorz Maj   +4 more
doaj   +1 more source

Application of gradient elasticity to benchmark problems of beam vibrations

Journal of the Mechanical Behavior of Materials, 2016
The gradient approach, specifically gradient elasticity theory, is adopted to revisit certain typical configurations on mechanical vibrations. New results on size effects and scale-dependent behavior not captured by classical elasticity are derived ...
Kateb K.M., Almitani K.H., Alnefaie K.A., Abu-Hamdeh N.H., Papadopoulos P., Askes H., Aifantis E.C.   +6 more
doaj   +1 more source

A Study of the Behavior of Shell Footings using Finite Element Analysis [PDF]

Engineering and Technology Journal, 2013
In this research, the conical shell foundation is investigated. The two components of the interacting system; the soil and the shell foundation, are modelled using the finite element method.
Adel A. Al-Azzawi
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Analytical surfaces for architecture and engineering

Structural Mechanics of Engineering Constructions and Buildings, 2022
Geometers have proposed more than 600 analytical surfaces for implementation. The largest number of these surfaces is used in architecture and mechanical engineering.
Mathieu Gil-Oulbé, Tiékolo Daou, Ousmane Mariko   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Finite element method studies on the stability behavior of external radial loaded cylindrical shells with varying dimensions [PDF]

, 2012
With the help of FEM and ANSYS, the influence of varying dimensions and sections, was tested on the structural behavior of cylindrical shells under external radial load. First, the theoretical concepts concerning cylindrical shells are described.
Equiza Lacabe, Javier
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source