Results 41 to 50 of about 737,442 (312)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development and Application of Mechanical Shield Tail Clearance Measurement Device Based on Angle Sensor

Chengshi guidao jiaotong yanjiu
Objective In view of the constant changes of shield tail clearance during shield or tunnel boring machine excavation process, to ensure construction safety, it is necessary to measure shield tail clearance in real-time. Addressing the shortcomings of non-
WANG Wei, YANG Guang, LIU Jiajun, WANG Junjie, WANG Liming   +4 more
doaj   +1 more source

The deposition of miniature weaponry in Iron Age Lincolnshire

Pallas, 2011
To appreciate the significance of miniatures, we must remove them from the category of archaeological curiosities and return them to their wider social and landscape contexts.
Julia Farley
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Data-driven prediction of unconfined compressive strength in stabilized soils using machine learning

Discover Applied Sciences
Accurately predicting the unconfined compressive strength (UCS) of Stabilized soil is essential for advancing sustainable geotechnical engineering practices.
Zhanpeng Luo, Xuecheng Xue, Chunlin Xiong, Renjie Huang, Jingjin Du, Junzan Li, Kaihua Liu   +6 more
doaj   +1 more source

Experimental Study on Slurry Improvement and Gushing Control in Water-rich Silty Fine Sand Layers

Chengshi guidao jiaotong yanjiu
[Objective] During EPB (earth pressure balance) shield tunneling through the water-rich silty fine sand layers, the ground is characterized by high friction, poor flow plasticity, and strong permeability.
GUO Shiqing, CHEN Han, JIANG Peifeng, GUO Pengfei, SUN Yi, XU Pingbao, DI Honggui   +6 more
doaj   +1 more source

The effects of environmental and classroom noise on the academic attainments of primary school children [PDF]

, 2008
While at school children are exposed to various types of noise including external, environmental noise and noise generated within the classroom. Previous research has shown that noise has detrimental effects upon children?s performance at school ...
Dockrell, Julie, Shield, Bridget
core   +1 more source

Electromagnetic losses in magnetic shields for buried high voltage cables [PDF]

, 2011
The electromagnetic losses and shielding efficiency of shields for a buried three phase high voltage cable are studied for several shielding configurations.
Koroglu, Selim, Sergeant, Peter
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Detection and Monitoring of Tunneling-Induced Riverbed Deformation Using GPS and BeiDou: A Case Study

Applied Sciences, 2019
Shield tunneling under rivers often requires monitoring riverbed deformations in near real-time. However, it is challenging to measure riverbed deformation with conventional survey techniques.
Wen Guo, Guoquan Wang, Yan Bao, Pengfei Li, Mingju Zhang, Qiuming Gong, Rui Li, Yang Gao, Ruibin Zhao, Shuilong Shen   +9 more
doaj   +1 more source