Results 61 to 70 of about 737,442 (312)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
矿业科学学报, 2021 The floating of the shield segment will cause the segment to be misaligned and damaged, reducing the overall structural strength, waterproof performance and service life of the tunnel.
Yang Zhiyong +5 more
doaj +1 more source
Small foamed polystyrene shield protects low-frequency microphones from wind noise [PDF]
, 1964 A foamed polystyrene noise shield for microphones has been designed in teardrop shape to minimize air turbulence. The shield slips on and off the microphone head easily and is very effective in low-frequency sound intensity ...
Tedrick, R. N.
core +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective It is aimed to tackle the inefficient accuracy of traditional Euler-Bernoulli beam and Winkler foundation model in calculating settlement induced by shield under-passing existing tunnels. Method Based on the Timoshenko beam theory and Pasternak
WANG Liang +3 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Permanent Shaft Repair Technology for Damaged Shield Segments in Operating Metro Tunnels
Chengshi guidao jiaotong yanjiu[Objective] During the drilling construction of ground surface dewatering shaft in a metro operational interval shield tunnel, the tunnel segments were damaged due to being pierced, resulting in sudden water hazards to interrupt metro service.
Fengyu LIAN +3 more
doaj +1 more source
Lithosphere-asthenosphere system in shield areas of North America and Europe
Annals of Geophysics, 1997 In previous papers surface dispersion data have been combined with the results of deep seismic refraction data to derive a regionalization of the lithosphere-asthenosphere system and to investigate the presence of significant heterogeneity down to depths
P. Pierri, V. Del Gaudio, G. Calcagnile
doaj +1 more source
Nuclear radiation problems, unmanned thermionic reactor ion propulsion spacecraft [PDF]
, 1972 A nuclear thermionic reactor as the electric power source for an electric propulsion spacecraft introduces a nuclear radiation environment that affects the spacecraft configuration, the use and location of electrical insulators and the science ...
Mondt, J. F. +2 more
core +1 more source