Results 61 to 70 of about 285,408 (262)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A Dynamic Shift-Share Analysis of Economic Growth in West Virginia
Journal of Rural and Community Development, 2012 A regional economy consists of industries with a variety of economic potentials. A growth or decline in any of these sectors affects the overall growth of the economy.
Saman Janaranjana Herath Bandara +2 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Reflexos territoriais do processo de reestruturação industrial em Portugal Continental na década de oitenta [PDF]
Finisterra - Revista Portuguesa de Geografia, 1996 INDUSTRIAL RESTRUCTURING IN PORTUGAL IN THE EIGHTIES - This paper analyses the territorial changes un manufacturing activity in mainland Portugal during the eighties. A shift-share analysis was applied to regional employment.
Nuno Costa, Eduarda Costa
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An Approach to an Intersection Traffic Delay Study Based on Shift-Share Analysis
Information, 2015 Intersection traffic delay research has traditionally placed greater emphasis on the study of through and left-turning vehicles than right-turning ones, which often renders existing methods or models inapplicable to intersections with heavy pedestrian ...
Jianfeng Xi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
European Transport Research Review, 2019 Resulting from the 21st UN Climate Change Conference (COP21) in Paris in 2015, the European Union’s (EU) current climate and energy objective is to reduce greenhouse gas (GHG) emissions by 40% below 1990 levels by 2030, and transportation must play a ...
Olaf Jonkeren, Jan Francke, Johan Visser
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source