Results 81 to 90 of about 1,903,292 (306)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
European Transport Research Review, 2019 Resulting from the 21st UN Climate Change Conference (COP21) in Paris in 2015, the European Union’s (EU) current climate and energy objective is to reduce greenhouse gas (GHG) emissions by 40% below 1990 levels by 2030, and transportation must play a ...
Olaf Jonkeren, Jan Francke, Johan Visser
doaj +1 more source
The evolution of the employment in the European Union. A stochastic shift and share approach [PDF]
The employment is a main economic variable whose evolution has shown different dynamics within the European Union. Recent papers have recovered the significance of the sectoral factors in the explanation of the regional growth.
López Menéndez, Ana Jesús +1 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The spatial shift-share analysis - new developments and some findings for the Spanish case [PDF]
The main feature of shift-share analysis is, according to Dunn (1960), the computation of geographical shifts in economic activity. Nevertheless, the traditional shift-share approach does not include explicitly the interaction between the considered ...
Ana Jesús López Menéndez +1 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Reflexos territoriais do processo de reestruturação industrial em Portugal Continental na década de oitenta [PDF]
Finisterra - Revista Portuguesa de Geografia, 1996 INDUSTRIAL RESTRUCTURING IN PORTUGAL IN THE EIGHTIES - This paper analyses the territorial changes un manufacturing activity in mainland Portugal during the eighties. A shift-share analysis was applied to regional employment.
Nuno Costa, Eduarda Costa
doaj
Regional Economic growth and accessibility: The case of the Netherlands [PDF]
, 1998 Shift-share is a popular, relatively easy to apply, tool in spatial analysis. Upon its initial development and use in the 1970s the literature has shown that serious drawbacks of the shift-share technique should be noted (e.g., lack of theoretical basis,
Florax, Raymond J.G.M. +3 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Path Based Shift-Share Analysis -Using Additional Information in Decomposing Regional Economic Changes [PDF]
Shift-Share analysis is a well-known methodology frequently used to obtain insights into the determinants of regional growth processes. It can address many issues, such as output growth, employment growth and productivity growth.
Bart Los +2 more
core