Results 61 to 70 of about 60,300 (260)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Unitary Shift Operators on a Graph
CoRR, 2019 A unitary shift operator (GSO) for signals on a graph is introduced, which exhibits the desired property of energy preservation over both backward and forward graph shifts. For rigour, the graph differential operator is also derived in an analytical form.
Bruno Scalzo Dees +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
An operator inequality for weighted Bergman shift operators
Revista Matemática Iberoamericana, 2013 We prove an operator inequality for the Bergman shift operator on weighted Bergman spaces of analytic functions in the unit disc with weight function controlled by a curvature parameter \alpha assuming nonnegative integer values.
Olofsson, Anders, Wennman, Aron
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the fine spectrum of the generalized difference operator B(r,s) over the sequence spaces c0 and c
International Journal of Mathematics and Mathematical Sciences, 2005 We determine the fine spectrum of the generalized difference operator B(r,s) defined by a band matrix over the sequence spaces c0 and c, and derive a Mercerian theorem.
Bilâl Altay, Feyzı Başar
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Geometric Characterizations of the Differential Shift Plus Alexander Integral Operator
International Journal of Analysis and Applications, 2017 In this effort, we deal with a new integral operator in the open unit disk. This operator is formulated by the complex Alexander operator and its derivative.
Rabha W. Ibrahim
doaj +2 more sources
Some Embeddings into the Morrey and Modified Morrey Spaces Associated with the Dunkl Operator
Abstract and Applied Analysis, 2010 We consider the generalized shift operator, associated with the Dunkl operator Λα(f)(x)=(d/dx)f(x)+((2α+1)/x)((f(x)-f(-x))/2), α>-1/2.
Emin V. Guliyev, Yagub Y. Mammadov
doaj +1 more source