Results 21 to 30 of about 56,619 (260)

Boolean feedback functions for full-length nonlinear shift registers

Journal of Telecommunications and Information Technology, 2004
In the paper a heuristic algorithm for a random generation of feedback functions for Boolean full-length shift register sequences is presented. With the help of the algorithm one can generate n-stage Boolean full-length shift register sequences for ...
Izabela Janicka-Lipsk, Janusz Stokłos
doaj   +1 more source

The register shift rules for βαβ-motifs for de novo protein design.

PLoS ONE, 2021
A wide range of de novo design of αβ-proteins has been achieved based on the design rules, which describe secondary structure lengths and loop torsion patterns favorable for design target topologies.
Hiroto Murata, Hayao Imakawa, Nobuyasu Koga, George Chikenji   +3 more
doaj   +1 more source

Mathematical approximator based on basic spline approximation [PDF]

E3S Web of Conferences
The article considers the problem of constructing a mathematical piecewise linear approximator based on approximation by basis splines. An algorithm has been developed designed to implement a class of special functions and create parallel ...
Turdimatov Mamirjon, Mukhtarov Farrukh, Ibrokhimov Nodirbekh, Umarov Shukhratjon, Mirzayev Jamshid, Rakhmatov Rasuljon   +5 more
doaj   +1 more source

A New, Fast Pseudo-Random Pattern Generator for Advanced Logic Built-In Self-Test Structures

Applied Sciences, 2021
Digital cores that are currently incorporated into advanced Systems on Chip (SoC) frequently include Logic Built-In Self-Test (LBIST) modules with the Self-Test Using MISR/Parallel Shift Register Sequence Generator (STUMPS) architecture.
Tomasz Garbolino
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Universal shift register implementation using quantum dot cellular automata

Ain Shams Engineering Journal, 2018
Quantum-dot Cellular Automata (QCA) demands to be a promising alternative of CMOS in ultra large scale circuit integration. Arithmetic and logic unit designs using QCA are of high research interest. A layout of four and eight bit universal shift register
Tamoghna Purkayastha, Debashis De, Tanay Chattopadhyay   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source