Results 51 to 60 of about 192,353 (293)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Constant-voltage drive current-steering switch [PDF]
, 1970 Two-element voltage control system regulates a magnetic switch consisting of dual ferrite-core shift registers.
Caplette, R. K.
core +1 more source
Branch prediction apparatus, systems, and methods [PDF]
, 2011 An apparatus and a system, as well as a method and article, may operate to predict a branch within a first operating context, such as a user context, using a first strategy; and to predict a branch within a second operating context, such as an operating ...
John, Lizy K., Li, Tao
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MORA - an architecture and programming model for a resource efficient coarse grained reconfigurable processor [PDF]
, 2009 This paper presents an architecture and implementation details for MORA, a novel coarse grained reconfigurable processor for accelerating media processing applications. The MORA architecture involves a 2-D array of several such processors, to deliver low
Chalamalasetti, S.R. +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Counting digital filters [PDF]
, 1973 Several embodiments of a counting digital filter of the non-recursive type are disclosed. In each embodiment two registers, at least one of which is a shift register, are included. The shift register received j sub x-bit data input words bit by bit.
Zohar, S.
core +1 more source
Duality of Channel Encoding and Decoding - Part I: Rate-1 Binary Convolutional Codes
, 2016 In this paper, we revisit the forward, backward and bidirectional Bahl-Cocke-Jelinek-Raviv (BCJR) soft-input soft-output (SISO) maximum a posteriori probability (MAP) decoding process of rate-1 binary convolutional codes.
Bahl +7 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source