Results 221 to 230 of about 1,577,013 (279)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

A unifying approach to shift design and rotating workforce scheduling

Tristan Becker
openalex   +1 more source

Associated factors and a risk prediction model for comorbid circadian rhythm sleep-wake disorders in patients with chronic fatigue syndrome: implications for early screening and sleep health management. [PDF]

Front Psychiatry
Shao X, Yang F, Qin LL, Shi JN, Chen M, Ge WJ, Jiang TJ, Yue JW, Feng W, Wang JH, Zhang ZX.   +10 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Perceived Mental Health and Occupational Stress of the Managerial Employees Under Different Shift Schedules

Azizur Rahman, Md. Kamal Uddin
  +4 more sources

Integrated shift and break scheduling for airline ground staff under flight delay uncertainty

Jeroen Assink, Mahekha Dahanayaka, Dennis Prak, Renu Gupta, Martijn Mes   +4 more
openalex   +1 more source

Evaluation of an AI-Based Constraint-Optimization Scheduler to Optimize On-Call Schedule Equity and Reduce Administrative Burden in a Pediatric Residency: Retrospective Comparative Study. [PDF]

J Med Internet Res
Gilad D, Farbstein-Aljanati T, Kassif Lerner R, Ashkenazi M, Pessach IM.   +4 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Diet Quality and Mental Health Outcomes Among Firefighters on Alternative Shift Schedules

Tuba Khan, Jill Joyce, Abby Fleming, Rachel A. Liebe, Pamela González Sánchez   +4 more
openalex   +1 more source

Circadian Neurology. [PDF]

Continuum (Minneap Minn)
Abbott SM.
europepmc   +1 more source