Results 51 to 60 of about 25,770,350 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cybergeo, 2011 Economic studies on micro-territorial settings have received growing attention in the social sciences, highlighting the complexity of social and economic mechanisms in macro-economic dynamics. The aim of this paper is to analyze the spatial influences on
Massimo Pasquariello
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Differences in the land rent among EU countries
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 The aim of the paper is to assess the differences in the influence of land rent on farm production efficiencies by region, farming type and LFA. In terms of the cost of rents there are significant differences among countries within the European Union ...
Jana Lososová +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Employment Changes in the European Economic Community: A Shift-Share Analysis [PDF]
Review of Regional Studies, 1995 The countries that make up the EC ” … are well into the process of complete economic integration” (Hailstones and Mastrianna 1991). The EC has become an established free trade zone and as such has become a relatively homogeneous economic region. While many studies have investigated the overall impact of the EC, few have focused on intraregional ...
Margaret A. Ray, John T. Harvey
openaire +2 more sources
Theory, Methodology, Practice, 2011 Increasing the accommodation supply is a top priority of tourism development at present. Tourism in Hungary has shown significant results since the 90s.
Zsolt Péter
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analysis of Emigration in Europe Using the Spatial Dynamic Shift-Share Method
Folia Oeconomica Stetinensia, 2015 The aim of the paper is to examine the pace of change in emigration levels in 24 selected European countries from 1999 to 2012, by age, country and the reference area. The spatial dynamic shift-share method is used in this research.
Antczak Elżbieta +1 more
doaj +1 more source