Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
ANALISIS STRATEGI BISNIS DALAM MENINGKATKAN MARKET SHARE DENGAN MENGGUNAKAN PENDEKATAN ANALYSIS BUSINESS MODEL CANVAS (BMC) DAN SWOT ANALYSIS PADA PT. SEMEN INDONESIA DISTRIBUTOR DI PURWODADI [PDF]
, 2020 This study aims to analyze the business strategies implemented at PT Semen Indonesia Distributor in the face of changes in the market competition map for market share and to determine business strategies that have a competitive advantage in increasing ...
Widodo, Agus
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Europäische Metropolregionen in Deutschland – eine regionalökonomische Evaluation
Raumforschung und Raumordnung, 2010 For more than ten years the concept of European Metropolitan Regions is fixed in the German regional planning system. This article uses the shift-share-technique to assess the economic performance of the eleven German metropolitan areas based on a ...
Karsten M. Rusche, Christian A. Oberst
doaj +1 more source
Defining Scenarios through shift - share models. An Application to the regional employment [PDF]
The analysis of different economic situations and risk factors is necessary in order to properly define forecasting scenarios. In this paper we focus on the shift-share model as a useful tool in the definition of economic scenarios, based on the ...
Rigoberto Pérez Suárez +2 more
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The Causes of the decreasing Population at remote areas in Iwate prefecture : An empirical study using Shift-Share analysis [PDF]
, 1999 過疎地域の振興は21世紀を目前に控えた今日においても依然として重要な課題である。高度成長期に起源を持つこの課題を解決するために数次に渡る過疎対策が実施されてきたわけであるが、これがどのような成果を挙げてきたのか、また、今後あるべき過疎対策とは何か、我々はまだはっきりした答えを持っていない。過疎対策の在り方を論じる上で、過疎が発生するメカニズムを明らかにすることは2つの意味で重要と考えられる。第一に、対症療法に過ぎない過疎対策からの脱却を図る手段を提供すること、第二に ...
1932 +9 more
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Spatial Shift-Share Analysis of the Leisure and Hospitality Sector on the Gulf Coast following Hurricane Katrina [PDF]
Employment shifts in the Leisure and Hospitality sector along the Gulf coast following Hurricane Katrina were explored using spatial shift-share analysis.
Evans, Garen K.
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Regional and structural factors in Swedish regional growth during the 1990s
Cybergeo, 2006 Based on the Swedish Standard Industrial Classification and individual longitudinal data, by using the shift-share analysis method, Swedish regional employment growth during the 1990s has been decomposed into two components—growth due to an endogenous ...
Li Wenjuan
doaj +1 more source