Results 141 to 150 of about 24,131,008 (297)

Shift - share analysis as a linear model

open access: yes
Shift - share analysis continues to be popular among geographers, regional scientists, and planners despite widespread criticism of the method. In this paper, it is argued that insufficient attention has been paid to model-based approaches to shift ...
D C Knudsen, R Barff
core  

Gender research strategy

open access: yes
The primary goal of SHiFT’s gender-responsive food system research is to support the achievement of the SHiFT initiative’s objectives through greater attention to gender issues (Table 1).
SHiFT
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A SUMMARY OF THE LITERATURE ON SHIFT-SHARE ANALYSIS [PDF]

open access: yes
Shift-share analysis is a method of decomposing regional income or employment growth patterns into expected (share) and differential (shift) components. Since its inception in the 1940s, over seventy academic contributions have criticized, defended, and ...
Loveridge, Scott, Selting, Anne C.
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

EKONOMI REGIONAL PROVINSI SULAWESI TENGGARA: Pendekatan Sektor Basis dan Analisis Input‐Output

open access: yesJurnal Ekonomi & Studi Pembangunan, 2009
This paper aims to study regional economic in Southeast Sulawesi Province. Analyse in this paper used export based approach and input-output analysis. This study found that (1) agriculture sector, construction, transport & communication, and service ...
Sri Subanti, Arif Rahman Hakim
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

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