Results 31 to 40 of about 285,452 (262)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Efeitos regionais do Mercosul: uma análise diferencial-estrutural para o período 1990-1995

open access: yesEconomia Aplicada, 1999
The objective of this paper is to analyse the impacts of Brazilian trade with the other Mercosur countries on the regional production of industries in Brazil, from 1990 through 1995.
Honório Kume, Guida Piani
doaj  

Competitiveness of cities in Croatia: analysis of employment dynamics 2001-2019

open access: yesGeoadria, 2022
The aim of this paper is to investigate the growth dynamics of 20 larger Croatian cities, macro-regional and regional centres, in order to indicate changes in their competitiveness.
Zdenko Braičić   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

PENGEMBANGAN POTENSI UNGGULAN SEKTOR PERTANIAN

open access: yesJurnal Ekonomi & Studi Pembangunan, 2010
In regional autonomy era, regional government obligated plan and control condition macroeconomics based on the condition of objective. Entire sectors of the economy is expected to develop and encourage other economic sectors.
Nano Prawoto
doaj  

Sugarcane expansion in the microregion of Araraquara: a shift-share analysis

open access: yesRevista Brasileira de Engenharia de Biossistemas
Sugarcane is one of the main crops in Brazilian agribusiness, covering a vast planted area that expands annually. Based on this, it is important to understand how the dynamics of this expansion occurred, to visualize whether there was the replacement of
Leticia Sarri dos Santos   +3 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Analisi del valore aggiunto pro capite: una tassonomia dei Sistemi Locali del Lavoro italiani attraverso la shift-share analysis con struttura spaziale

open access: yesCybergeo, 2011
Economic studies on micro-territorial settings have received growing attention in the social sciences, highlighting the complexity of social and economic mechanisms in macro-economic dynamics. The aim of this paper is to analyze the spatial influences on
Massimo Pasquariello
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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