Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Shift-Share Analysis: Review of Spatial Versions
Regionalistica, 2022 The article presents the genesis of spatial shift-share analysis. The author focuses on the links of spatial versions of shift-share analysis with the classical one, which is not just a starting point for them from a historical point of view, but retains the status of their constituent element.
openaire +1 more source
The spatial shift-share analysis - new developments and some findings for the Spanish case [PDF]
The main feature of shift-share analysis is, according to Dunn (1960), the computation of geographical shifts in economic activity. Nevertheless, the traditional shift-share approach does not include explicitly the interaction between the considered ...
Ana Jesús López Menéndez +1 more
core
, 2021 Research examining the prevalence, physical activity (PA) and sedentary behaviour (SB) in shift workers show mixed results. This systematic review and meta-analysis aimed to compare PA and SB in shift workers with non-shift workers following the PRISMA ...
Monnaatsie, Malebogo +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ANALISIS STRATEGI BISNIS DALAM MENINGKATKAN MARKET SHARE DENGAN MENGGUNAKAN PENDEKATAN ANALYSIS BUSINESS MODEL CANVAS (BMC) DAN SWOT ANALYSIS PADA PT. SEMEN INDONESIA DISTRIBUTOR DI PURWODADI [PDF]
, 2020 This study aims to analyze the business strategies implemented at PT Semen Indonesia Distributor in the face of changes in the market competition map for market share and to determine business strategies that have a competitive advantage in increasing ...
Widodo, Agus
core
Europäische Metropolregionen in Deutschland – eine regionalökonomische Evaluation
Raumforschung und Raumordnung, 2010 For more than ten years the concept of European Metropolitan Regions is fixed in the German regional planning system. This article uses the shift-share-technique to assess the economic performance of the eleven German metropolitan areas based on a ...
Karsten M. Rusche, Christian A. Oberst
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Defining Scenarios through shift - share models. An Application to the regional employment [PDF]
The analysis of different economic situations and risk factors is necessary in order to properly define forecasting scenarios. In this paper we focus on the shift-share model as a useful tool in the definition of economic scenarios, based on the ...
Rigoberto Pérez Suárez +2 more
core
The Causes of the decreasing Population at remote areas in Iwate prefecture : An empirical study using Shift-Share analysis [PDF]
, 1999 過疎地域の振興は21世紀を目前に控えた今日においても依然として重要な課題である。高度成長期に起源を持つこの課題を解決するために数次に渡る過疎対策が実施されてきたわけであるが、これがどのような成果を挙げてきたのか、また、今後あるべき過疎対策とは何か、我々はまだはっきりした答えを持っていない。過疎対策の在り方を論じる上で、過疎が発生するメカニズムを明らかにすることは2つの意味で重要と考えられる。第一に、対症療法に過ぎない過疎対策からの脱却を図る手段を提供すること、第二に ...
1932 +9 more
core