Results 101 to 110 of about 24,935,845 (250)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Perspective clusters in Slovakia: the case of Banská Bystrica region
Forum Scientiae Oeconomia, 2016 The paper focuses on the identification of perspective clusters in BanskáBystrica region. It uses national and regional data about the employment and anal-yses the regional and industrial share of businesses on the total employment (both in Slovakia and
Ľuboš Elexa +3 more
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Klasifikasi Pertumbuhan, Sektor Basis dan Kompetitif Kota Jambi [PDF]
Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2015 This study aims to determine the classification of economic growth in the city of Jambi, base and non-base sectors in the economy of the city of Jambi, Competitive sectors in the economy of the city of Jambi and to determine the leading sectors in Jambi ...
Yusral, Junaidi, Adi Bhakti
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
POST-CRISIS ECONOMIC SPECIALISATION PATTERNS OF ARGES COUNTY IN ROMANIA AND THE EU. MOVING TOWARDS SMART SPECIALIZATION [PDF]
Strategii Manageriale, 2013 Under the new European regional policy framework for 2014 – 2020, smart specialization is a key issue meant to highglight the unique characteristics and assets of each country/ region and to rally regional stakeholders and resources around an excellence ...
Ovidiu, PUIU, Cristina, SERBANICA
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A SUMMARY OF THE LITERATURE ON SHIFT-SHARE ANALYSIS [PDF]
Shift-share analysis is a method of decomposing regional income or employment growth patterns into expected (share) and differential (shift) components. Since its inception in the 1940s, over seventy academic contributions have criticized, defended, and ...
Loveridge, Scott, Selting, Anne C.
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source