Results 31 to 40 of about 293,216 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Efeitos regionais do Mercosul: uma análise diferencial-estrutural para o período 1990-1995
Economia Aplicada, 1999 The objective of this paper is to analyse the impacts of Brazilian trade with the other Mercosur countries on the regional production of industries in Brazil, from 1990 through 1995.
Honório Kume, Guida Piani
doaj
Competitiveness of cities in Croatia: analysis of employment dynamics 2001-2019
Geoadria, 2022 The aim of this paper is to investigate the growth dynamics of 20 larger Croatian cities, macro-regional and regional centres, in order to indicate changes in their competitiveness.
Zdenko Braičić +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
PENGEMBANGAN POTENSI UNGGULAN SEKTOR PERTANIAN
Jurnal Ekonomi & Studi Pembangunan, 2010 In regional autonomy era, regional government obligated plan and control condition macroeconomics based on the condition of objective. Entire sectors of the economy is expected to develop and encourage other economic sectors.
Nano Prawoto
doaj
Sugarcane expansion in the microregion of Araraquara: a shift-share analysis
Revista Brasileira de Engenharia de BiossistemasSugarcane is one of the main crops in Brazilian agribusiness, covering a vast planted area that expands annually. Based on this, it is important to understand how the dynamics of this expansion occurred, to visualize whether there was the replacement of
Leticia Sarri dos Santos +3 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Cybergeo, 2011 Economic studies on micro-territorial settings have received growing attention in the social sciences, highlighting the complexity of social and economic mechanisms in macro-economic dynamics. The aim of this paper is to analyze the spatial influences on
Massimo Pasquariello
doaj +1 more source