Results 181 to 190 of about 293,216 (302)

Shifting barriers to health care access: from affordability to coverage issues. [PDF]

BMC Health Serv Res
League R, Mahmoudi Meymand M.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Toward a global paradigm shift: integrating neuroplasticity, cultural sensitivity, and scalable interventions in chronic pain. [PDF]

Korean J Pain
Lacsa JEM.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Dynamic copay health plans, AI-enabled price transparency, and member experience. [PDF]

Health Aff Sch
Debbarma A, Dowd BE.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Sequence-encoded differences in the conformational ensembles of CITED transcriptional activation domains impact coactivator binding. [PDF]

Protein Sci
Do TU, Kraft EJ, Chappell GF, Parnham S, Berlow RB.   +4 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Cutting Carbon with Knife and Bin: The Role of Diet and Food Recycling in the Food System of Ulaanbaatar, Mongolia. [PDF]

Foods
Bold A, Cui S, Yin J, Huang W, Tsog T, Munkhbaatar D, Batbayar G.   +6 more
europepmc   +1 more source

Teaching Regional Economics with interactive software: the case of Shift-Share analysis [PDF]

Skuras, Dimitris, Roussos, Athanasios
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