Results 211 to 220 of about 1,432,960 (308)

Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia. [PDF]

Front Public Health
Zhao X, Wang W, Li N, Gao Y, Yu L, Song M, Wang X, Wang L.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Night-shift work and its association with metabolic syndrome. [PDF]

Medicine (Baltimore)
Lin SC, Yeh WC, Liu ZX, Hsu HF, Chen JY.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Characterising the impact of shift work on diet and glucose variability in healthcare employees living with type 2 diabetes: The Shift-Diabetes study. [PDF]

Diabet Med
Gibson R, D'Annibale M, Palla L, Tejo F, McGowan B, Vetter C, Lorencatto F, Oliver N, Guess N.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Night shift work and dietary behaviors: a comparative analysis of European night shift and day workers from the SHIFT2HEALTH online survey. [PDF]

Nutr J
Klink U, Feskens EJM, Lucassen DA, Vingerhoeds MH, Haider S, Papantoniou K, Matullat I, Cuparencu C, Aufschnaiter AL, Fuchs-Neuhold B, Höfler C, Wallner M, Binder-Olibrowska KW, Wrzesińska MA, Lammers-van der Holst HM, Santonja I, Scionti K, Schoissengeier V, Wagner KH, Wakolbinger M, Winzer E, Ummels M, Jilani H, SHIFT2HEALTH consortium.   +23 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Association of shift work with metabolic dysfunction-associated fatty liver disease among subway workers. [PDF]

Front Public Health
Peng R, Shi B, Liu J, He Z.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source