Results 111 to 120 of about 15,095,322 (254)

Parasomnias related to shift work disorder among medical residents during the first year of training in Mexico. [PDF]

Sleep Biol Rhythms, 2023
Ariza-Serrano J, Santana-Vargas D, Millan-Rosas G, Santana-Miranda R, Rosenthal L, Poblano A.   +5 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Factors Associated with Workplace Injuries Among Shift Work Nurses: A Cross-Sectional Study in an Ecuadorian Sample

Nursing Reports
Background/Objectives: Shift work schedules and mental and physical workloads affect the sleep homeostasis of nurses, increasing the risk of occupational injuries.
Germán Prados, Ángela Mendoza-Vinces, Martha Holguín, Jacobo Cambil-Martín, Laura Fernández-Puerta   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Gender research strategy

The primary goal of SHiFT’s gender-responsive food system research is to support the achievement of the SHiFT initiative’s objectives through greater attention to gender issues (Table 1).
SHiFT
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Shift workers’ experiences and views of sleep disturbance, fatigue and healthy behaviors: a systematic review and qualitative evidence synthesis

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: Shift work is common across most societies but poses significant risks to the health of shift workers. In part, this risk is due to the disruption of healthy sleep-wake schedules. This systematic review identified qualitative research on shift
Jack S Benton, Charlotte L Lee, Hannah A Long, Thavapriya Sugavanam, Leah Holmes, Annie Keane, Neal Thurley, Simon Kyle, David Ray, David P French   +9 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The shift team formation problem in multi-shift manufacturing operations [PDF]

This paper addresses the problem of assigning operators to teams that work in single-, two-, or three-day shift systems. The problem was motivated by, and illustrated with a case situation encountered in Dutch manufacturing industry.
Suresh, Nallan C., Slomp, Jannes
core  

Eating and shift work – effects on habits, metabolism and performance

, 2010
Compared to individuals who work during the day, shift workers are at higher risk of a range of metabolic disorders and diseases (eg, obesity, cardiovascular disease, peptic ulcers, gastrointestinal problems, failure to control blood sugar levels, and ...
Löwden, Arne,, Holmbäck, Ulf C.,, Moreno, Claudia Roberta,, Lennernäs, Maria,, Tucker, Philip T.,, Wiklund, Maria Lennernäs,, Moreno, C.R.C.,, Ulf Holmbäck, Philip Tucker, Arne Lowden, Claudia Moreno, Maria Lennernäs   +11 more
core   +1 more source