Results 91 to 100 of about 50,731 (262)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

What Determines Step-Rate at Work? An Investigation of Factors at the Shift, Worker, Ward, and Nursing Home Levels in Eldercare. [PDF]

Ann Work Expo Health, 2021
Stevens ML, Karstad K, Mathiassen SE, Januario LB, Holtermann A, Hallman DM.   +5 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Sleep Quality and Restless Legs Syndrome among Healthcare Workers: Shift Workers and Non-Shift Workers

Journal of Sleep Sciences, 2016
Background and Objective: Restless legs syndrome (RLS) is a sleep disorder with an association to sleep quality. We investigated the sleep quality in patients with RLS among health-care workers with or without shift work. Materials and Methods: All female health-care workers (n = 540) in four educational hospitals were enrolled in this cross-sectional ...
Zahra Banafsheh Alemohammad, Seyed Mohammad Esmaeil Taghavi, Akbar Sharifian   +2 more
openaire   +2 more sources

The effect of a night shift nap on post-night shift performance, sleepiness, mood, and first recovery sleep: A randomized crossover trial

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: This study aimed to test the effect of a 30-minute nap versus a 2-hour nap opportunity taken during a simulated night shift on performance, fatigue, sleepiness, mood, and sleep at the end of shift and during post-night shift recovery. METHODS:
P Daniel Patterson, Cassie J Hilditch, Matthew D Weaver, David GL Roach, Tiffany S Okerman, Sarah E Martin, Charity G Patterson, Leonard S Weiss   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Night shift work and risk of total and site-specific cancer: results from a prospective cohort study among Chinese men

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: Epidemiological evidence on the association between night shift work and cancer risk remains limited and inconsistent. This study aimed to systematically investigate this association among Chinese men.
Qiu-Ming Shen, Zhuo-Ying Li, Yu-Ting Tan, Li-Feng Gao, Da-Ke Liu, Hong-Lan Li, Wan-Shui Yang, Yong-Bing Xiang   +7 more
doaj   +1 more source

Night work and hypertensive disorders of pregnancy: a national register-based cohort study

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVE: The aim of this study was to investigate whether night work expressed by number and duration of night shifts, number of consecutive night shifts, and number of quick returns during the first 20 weeks of pregnancy is a risk factor for ...
Paula Hammer, Esben Flachs, Ina Specht, Anja Pinborg, Sesilje Petersen, Ann Larsen, Karin Hougaard, Johnni Hansen, Åse Hansen, Henrik Kolstad, Anne Garde, Jens Peter Bonde   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source