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Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025 [PDF]

Emerging Infectious Diseases
In January 2025, the Escherichia coli National Reference Center of France detected an outbreak of hemolytic uremic syndrome (HUS) in adults, caused by Shiga toxin–producing E. coli negative for locus of enterocyte effacement (LEE). The outbreak included
Justine de Larminat, Kevin La, Philippe Bidet, André Birgy, Sandrine Liguori, Pierre Phlipaux, Celine Courroux, Florence Crombé, Jorge Blanco, Paul Coppo, Antoine Dossier, Laurence Armand-Lefevre, François Xavier Weill, Carolina Silva Nodari, Gabrielle Jones, Aurelie Cointe, Stéphane Bonacorsi   +16 more
doaj   +2 more sources

Transforming Shiga toxin-producing Escherichia coli surveillance through whole genome sequencing in food safety practices

Frontiers in Microbiology, 2023
IntroductionShiga toxin-producing Escherichia coli (STEC) is a gastrointestinal pathogen causing foodborne outbreaks. Whole Genome Sequencing (WGS) in STEC surveillance holds promise in outbreak prevention and confinement, in broadening STEC epidemiology
Stéphanie Nouws, Stéphanie Nouws, Bavo Verhaegen, Sarah Denayer, Florence Crombé, Denis Piérard, Bert Bogaerts, Kevin Vanneste, Kathleen Marchal, Kathleen Marchal, Nancy H. C. Roosens, Sigrid C. J. De Keersmaecker   +11 more
doaj   +1 more source

Comparison of Two Shiga Toxin-producing Escherichia coli (STEC) Isolation Protocols in Raw Cow’s Milk Cheese Enrichment Broths: Direct STEC Isolation Versus Techniques Based on Immuno-concentration

Journal of Food Protection, 2023
The presence of Shiga toxin-producing Escherichia coli (STEC) in dairy products made with raw milk is a major concern for food safety authorities and industries. Two approaches have been proposed to isolate STEC from food.
Stephane D. Miszczycha, Christine Mazuy-Cruchaudet, Camille Thollet, Delphine Sergentet-Thevenot   +3 more
doaj   +1 more source

Towards Real-Time and Affordable Strain-Level Metagenomics-Based Foodborne Outbreak Investigations Using Oxford Nanopore Sequencing Technologies

Frontiers in Microbiology, 2021
The current routine laboratory practices to investigate food samples in case of foodborne outbreaks still rely on attempts to isolate the pathogen in order to characterize it.
Florence E. Buytaers, Florence E. Buytaers, Assia Saltykova, Assia Saltykova, Sarah Denayer, Bavo Verhaegen, Kevin Vanneste, Nancy H. C. Roosens, Denis Piérard, Kathleen Marchal, Kathleen Marchal, Sigrid C. J. De Keersmaecker   +11 more
doaj   +1 more source

Surface proteins of Shiga toxin-producing Escherichia coli mediate association with milk fat globules in raw milk

Frontiers in Microbiology, 2023
IntroductionBy adhering to host cells and colonizing tissues, bacterial pathogens can successfully establish infection. Adhesion is considered the first step of the infection process and bacterial adhesion to anti-adhesive compounds is now seen as a ...
Arthur Bagel, Marion Bouvier-Crozier, Marion Bouvier-Crozier, Mélissa Canizares, Badis Hamadou, Louise Courcol, Christelle Lopez, Valérie Michel, Thomas Douellou, Delphine Sergentet, Delphine Sergentet   +10 more
doaj   +1 more source

Volume Resuscitation and Progression to Organ Failure in Shiga Toxin-Producing Escherichia coli Infection in Adults

Critical Care Explorations, 2021
OBJECTIVES:. Shiga toxin-producing Escherichia coli infection is associated with dysentery and the hemolytic uremic syndrome, marked by the triad of microangiopathic hemolytic anemia, acute kidney failure, and thrombocytopenia.
Charles G. Volk, MD, Paul M. Cusmano, DO, Richard J. Bower, MD, Terrel Sanders, MD, Ryan C. Maves, MD   +4 more
doaj   +1 more source

A Practical Method to Implement Strain-Level Metagenomics-Based Foodborne Outbreak Investigation and Source Tracking in Routine

Microorganisms, 2020
The management of a foodborne outbreak depends on the rapid and accurate identification of the responsible food source. Conventional methods based on isolation of the pathogen from the food matrix and target-specific real-time polymerase chain reactions (
Florence E. Buytaers, Assia Saltykova, Sarah Denayer, Bavo Verhaegen, Kevin Vanneste, Nancy H. C. Roosens, Denis Piérard, Kathleen Marchal, Sigrid C. J. De Keersmaecker   +8 more
doaj   +1 more source

The Benefits of Whole Genome Sequencing for Foodborne Outbreak Investigation from the Perspective of a National Reference Laboratory in a Smaller Country

Foods, 2020
Gradually, conventional methods for foodborne pathogen typing are replaced by whole genome sequencing (WGS). Despite studies describing the overall benefits, National Reference Laboratories of smaller countries often show slower uptake of WGS, mainly ...
Stéphanie Nouws, Bert Bogaerts, Bavo Verhaegen, Sarah Denayer, Florence Crombé, Klara De Rauw, Denis Piérard, Kathleen Marchal, Kevin Vanneste, Nancy H. C. Roosens, Sigrid C. J. De Keersmaecker   +10 more
doaj   +1 more source

Hemolytic uremic syndrome related to Shiga-like toxin-producing Escherichia coli with encephalitis hiding a human herpesvirus-6 infection: a case report

Journal of Medical Case Reports, 2021
Background Cardiac and neurological involvement in hemolytic uremic syndrome are life-threatening complications. The most frequent complications of cardiac involvement in hemolytic uremic syndrome are myocarditis and cardiac dysfunction due to fluid ...
Sophie Mounier, Arthur Gavotto, Julie Tenenbaum, Pierre Meyer, Marc Fila, Julien Baleine   +5 more
doaj   +1 more source

Open-source genomic analysis of Shiga-toxin–producing E. coli O104:H4 [PDF]

, 2011
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic
Antoine Danchin, Cordesmeyer S, Dongfang Li, Fei Pu, Feng Xi, George F. Gao, Holger Rohde, Huanming Yang, Itoh Y, Jian Wang, Jianguo Xu, Jun Oh, Jun Wang, Junhua Li, Junjie Qin, Kuijper E, Liang Yang, Mark J. Pallen, Martin Aepfelbacher, Martin Christner, Meiru Zhao, Moritz Hentschke, Nicholas J. Loman, Peng Wang, Robin Kobbe, Ruifu Yang, Scheutz F, Sebastian Loos, Shenghui Li, Wentong Chen, Xiangna Zhao, Xianwei Yang, Yajun Song, Yangqing Peng, Yin Li, Yingrui Li, Yuanlin Guan, Yujun Cui, Zhaoxi Zhang, Zhong Cen   +39 more
core   +1 more source