Results 211 to 220 of about 29,285 (250)
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Entry of Shiga Toxin into Cells
Zentralblatt für Bakteriologie, 1993The effect of Shiga toxin with mutations in the A fragment has been tested on cells in order to get more information about the processing of the A fragment during entry into the cytosol. A mutant with a deletion between the A1 and A2 domain in the A fragment is resistant to cleavage by trypsin and is less toxic than wild type toxin on both Vero and ...
Sandvig, Kirsten +6 more
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Protection of Monkeys against Shiga Toxin Induced by Shiga Toxin-Liposome Conjugates
International Archives of Allergy and Immunology, 2002<i>Background:</i> We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against ...
Yuriko, Suzaki +14 more
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Diagnostic Microbiology and Infectious Disease, 2007
Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and ...
Dorothea, Orth +5 more
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Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and ...
Dorothea, Orth +5 more
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Shiga-toxin-converting bacteriophages
Research in Microbiology, 2001Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman sources, and by Shigella dysenteriae type 1. The genes encoding Stx are thought to be generally encoded in the genome of lambdoid prophages (Stx-converting bacteriophages; Stx ...
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Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3
The Journal of Infectious Diseases, 1992Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
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Affinity purification of Shiga-like toxin I and Shiga-like toxin II
Journal of Microbiological Methods, 1998Abstract A facile method is described for affinity purifying Shiga-like toxin I (verotoxin 1) or Shiga-like toxin II (verotoxin 2) from cell-free Escherichia coli culture supernatant solutions using immobilized synthetic analogs of the digalactoside [αGal(1,4)βGal] host cell receptor for these toxins.
George Mulvey, Glen D Armstrong
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Antibodies to Shiga toxins in Brazilian cattle
Toxicon, 2017Cattle are considered a reservoir of Shiga toxin-producing Escherichia coli (STEC). There is no information about the presence of antibodies against Shiga toxins in Brazilian bovine serum. Using ELISA, all sera tested showed antibodies against the two main STEC virulence factors; Stx1 and Stx2.
Bruno B, Yamamoto +6 more
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Effect of Shiga toxins on granulocyte function
Microbial Pathogenesis, 2002We already showed that injection of Shiga toxin (Stx) 2 into mice caused severe granulocytosis in the peripheral blood. In this study we further clarified changes of granulocyte function by Stx 2. The activity of medullasin, a neutral serine protease in granulocytes that injures endothelial cells in vessels, significantly increased when Stx 2 was ...
Yosuke, Aoki, Tac, Takeda
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Shiga Toxin: Purification, Structure, and Function
Clinical Infectious Diseases, 1991Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. It consists of two polypeptide chains, an A chain (molecular weight, 32,225) and a B chain (molecular weight, 7,691 ...
A, Donohue-Rolfe +2 more
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2000
Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
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Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
openaire +1 more source