Results 211 to 220 of about 123,037 (250)

Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells

Thrombosis and Haemostasis, 2011
SummaryShiga toxin (Stx)-mediated injury to vascular endothelial cells in the kidneys, brain and other organs underlies the pathogenesis of haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). We present a direct and comprehensive comparison of cellular injury induced by the two major Stx types, Stx1 and Stx2, in ...
Martina Bielaszewska, Björn Kemper, Hans-Ulrich Humpf   +2 more
exaly   +3 more sources

Neurotoxicity of intrathecal Shiga toxin 2 and protection by intrathecal injection of anti-Shiga toxin 2 antiserum in rabbits

Microbial Pathogenesis, 1998
The initial brain lesions in rabbits given intravenous Shiga toxin 2 (Stx2) were noted at 24 h in an area around the third ventricle (Fujii et al., Infect Immun 1996, 64: 5053-60). This result implied that Stx2 is present in the cerebrospinal fluid (CSF) despite the fact that the toxin was administered intravenously. We measured Stx2 activity in CSF by
J, Fujii, Y, Kinoshita, Y, Yamada, T, Yutsudo, T, Kita, T, Takeda, S, Yoshida   +6 more
openaire   +2 more sources

Particulate Shiga Toxin 2 in Blood is Associated to the Development of Hemolytic Uremic Syndrome in Children

Thrombosis and Haemostasis, 2019
Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections.
M. Brigotti, Xiaohua He, D. Carnicelli, Valentina Arfilli, E. Porcellini, Elisabetta Galassi, P. Tazzari, F. Ricci, Stephanie Patfield, S. Testa, F. Paglialonga, Damiano Picicco, A. Caprioli, G. Scavia, S. Morabito, G. Ardissino   +15 more
semanticscholar   +1 more source

A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection against Shiga toxin types 1 and 2

Vaccine, 2008
Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases. Their B-subunits (StxBs) exhibit low immunogenicity and the anti-StxB antibodies neutralizing both Stxs has not been prepared yet. By intranasal vaccination with His-tagged-StxB (Stx1B-His or Stx2B-His) plus a mutant heat-labile enterotoxin (mLT) in mice, their ...
Takao, Tsuji, Takeshi, Shimizu, Keiko, Sasaki, Kentaro, Tsukamoto, Hideyuki, Arimitsu, Sadayuki, Ochi, Toshiyasu, Shimizu, Koki, Taniguchi, Masatoshi, Noda, Paola, Neri, Hiroshi, Mori   +10 more
openaire   +2 more sources

Human Platelet Aggregation Is Not Altered by Shiga Toxins 1 or 2

Thrombosis Research, 2000
The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under resting or arterial-flow conditions
D, Viisoreanu, R, Polanowska-Grabowska, S, Suttitanamongkol, T G, Obrig, A R, Gear   +4 more
openaire   +2 more sources

Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin

Vaccine, 2008
Escherichia coli O157:H7 produces Stx1 and Stx2 causing severe diseases. Their B subunits (StxBs) are useful for a vaccine but exhibit low immunogenicity, especially Stx2B. Nasal vaccination with StxBs plus cholera toxin induces only serum anti-Stx1B antibodies in mice. However, nasal administration of a mutant of E.
Takao, Tsuji, Takeshi, Shimizu, Keiko, Sasaki, Yoshiyasu, Shimizu, Kentaro, Tsukamoto, Hideyuki, Arimitsu, Sadayuki, Ochi, Satoshi, Sugiyama, Koki, Taniguchi, Paola, Neri, Hiroshi, Mori   +10 more
openaire   +2 more sources

Genomic Insight into Natural Inactivation of Shiga Toxin 2 Production in an Environmental Escherichia coli Strain Producing Shiga Toxin 1

Foodborne Pathogens and Disease, 2020
Shiga toxin-producing Escherichia coli (STEC) consists of a group of diverse strains differing greatly in genetic make-up and pathogenicity potential. Here, we investigated production of Shiga toxins (Stxs) in a bovine isolate carrying multiple Shiga toxin genes (stxs) after exposure to several antibiotics commonly used in food animals.
Michelle Qiu, Carter, Antares, Pham, Xiaohua, He, Robert, Hnasko   +3 more
openaire   +2 more sources

Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2

Annals of Neurology, 2013
Objective The outbreak of hemolytic–uremic syndrome and diarrhea caused by Shiga toxin–producing Escherichia coli O104:H4 in Germany during May to July 2011 involved severe and characteristic neurologic manifestations with a strong female ...
S. Meuth, K. Göbel, T. Kanyshkova, Petra Ehling, M. Ritter, W. Schwindt, M. Bielaszewska, P. Lebiedz, Pierre-Gregoire A Coulon, A. Herrmann, W. Storck, Denise Kohmann, J. Müthing, H. Pavenstädt, T. Kuhlmann, H. Karch, G. Peters, T. Budde, H. Wiendl, H. Pape   +19 more
semanticscholar   +3 more sources

Development and characterization of monoclonal antibodies against Shiga toxin 2 and their application for toxin detection in milk.

Journal of Immunological Methods, 2013
Human infection by Shiga toxin producing Escherichia coli (STEC) is one of the most prevalent foodborne diseases. Shiga toxin type 2 (Stx2) is the major contributor to hemolytic-uremic syndrome (HUS) and other systemic complications caused by STEC. Although outbreaks of HUS due to the consumption of dairy products occur frequently, very few reports are
Xiaohua He, S. McMahon, Craig Skinner, P. Merrill, M. Scotcher, L. Stanker   +5 more
semanticscholar   +3 more sources

The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2

2014
Hemolytic uremic syndrome (HUS) is a potential life-threatening condition caused by infection with Shiga toxin-producing Escherichia coli O157:H7. There are two major types of Shiga toxins, namely, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), of which, Stx2 is clinically most closely associated with enterohemorrhagic E. coli O157:H7-mediated HUS. The
openaire   +1 more source