Results 81 to 90 of about 40,170 (206)

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Mitochondria mediate septin cage assembly to promote autophagy of Shigella [PDF]

, 2016
Septins, cytoskeletal proteins with well-characterised roles in cytokinesis, form cage-like structures around cytosolic Shigella flexneri and promote their targeting to autophagosomes.
Buranyi, S, Culley, S, Galea, D, Henriques, R, Hollinshead, M, Krokowski, S, Larrouy-Maumus, G, Lobato-Márquez, D, Mostowy, S, Pfanzelter, J, Sancho-Shimizu, V, Sirianni, A, Way, M, Willis, A   +13 more
core  

Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom [PDF]

, 2009
Prevalence of three sulfonamide resistance genes, sul1, sul2 and sul3 and sulfachloropyridazine (SCP) resistance was determined in bacteria isolated from UK manured agricultural clay soils and slurry samples, over a two year period.
Boxall, Alistair B.A., Byrne-Bailey, K. G., Gaze, William H., Hawkey, P. M., Kay, Paul, Wellington, E. M. H.   +5 more
core   +2 more sources

Hibiscus rosa‐sinensis: A Multifunctional Flower Bridging Nutrition, Medicine, and Molecular Therapeutics

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
H. rosa‐sinensis bioactives modulate oxidative and inflammatory pathways. Myricetin and rutin show strong α‐glucosidase and SOD binding affinity. Exhibits safe, multifunctional use in health, food and nutraceuticals. ABSTRACT Hibiscus rosa‐sinensis, commonly known as the shoe flower, thrives in tropical and subtropical regions across South China, Asia,
Hassan Raza, Muhammad Tauseef Sultan, Khalil Ahmad, Muhammad Maaz, Shehnshah Zafar, Ahmad Mujtaba Noman, Entessar Mohammad Al Jbawi   +6 more
wiley   +1 more source

Kemampuan Antibakteri Susu Fermentasi terhadap Escherichia coli dan Shigella

Jurnal Agripet, 2017
ABSTRAK. Penelitian ini dilakukan dengan menggunakan starter Lactobacillus plantarum pada konsentrasi 3%, 4% dan 5% dan diinkubasi selama 48 jam pada suhu kamar. Pengamatan terhadap susu fermentasi dilakukan selama 8 hari.
Zuraida Hanum, Rastina Rastina, Veronica Wanniatie   +2 more
doaj   +1 more source

Molecular Modeling of the Shigella flexneri Serogroup 3 and 5 O-Antigens and Conformational Relationships for a Vaccine Containing Serotypes 2a and 3a

Vaccines, 2020
The pathogenic bacterium Shigella flexneri is a leading global cause of diarrheal disease. The O-antigen is the primary vaccine target and distinguishes the 30 serotypes reported. Except for serotype 6, all S.
Jason Hlozek, Sara Owen, Neil Ravenscroft, Michelle M. Kuttel   +3 more
doaj   +1 more source

High‐Yield Outer Membrane Vesicles Derived From Probiotics as a Nanoplatform for Precise Treatment and Prophylaxis of Pseudomonas aeruginosa Infection

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT Bacterial outer membrane vesicles (OMVs) are emerging as promising platforms for drug delivery and immunotherapy. However, bacteria only secrete a small amount of OMVs during the growth process, which seriously restricts their large‐scale application.
Yadong Yang, Lei Xu, Yongdong Li, Yu Sun, Yanan Tang, Zhibo Xiao, Mengyuan Li, Yi Chen, Yao Wang, Xihui Shen   +9 more
wiley   +1 more source

Age-dependent acquisition of IgG antibodies to Shigella serotypes—a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination

Frontiers in Immunology
BackgroundShigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination.
Melissa C. Kapulu, Melissa C. Kapulu, Esther Muthumbi, Esther Muthumbi, Edward Otieno, Omar Rossi, Pietro Ferruzzi, Francesca Necchi, Alessandra Acquaviva, Laura B. Martin, Benedict Orindi, Kennedy Mwai, Kennedy Mwai, Hillary Kibet, Alfred Mwanzu, Godfrey M. Bigogo, Jennifer R. Verani, Cecilia Mbae, Christopher Nyundo, Charles N. Agoti, Usman Nasir Nakakana, Valentino Conti, Philip Bejon, Philip Bejon, Samuel Kariuki, J. Anthony G. Scott, J. Anthony G. Scott, Francesca Micoli, Audino Podda   +28 more
doaj   +1 more source

Comparative genome analysis of 15 clinical Shigella flexneri strains regarding virulence and antibiotic resistance

AIMS Microbiology, 2019
Shigellosis is the major cause of dysentery globally. It is mainly attributed to two Shigella species, Shigella sonnei and Shigella flexneri, which leads to approximately 165 million infections and 1.1 million deaths each year.
Liang Wang, Zuobin Zhu, Huimin Qian, Ying Li, Ying Chen, Ping Ma, Bing Gu   +6 more
doaj   +1 more source