Results 61 to 70 of about 75,960 (314)
EPI Update, March 22, 2013 [PDF]
, 2013 Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public ...
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
core +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Zoster vaccine live for the prevention of shingles in the elderly patient
Clinical Interventions in Aging, 2008 Jamie Zussman, Lorraine YoungDepartment of Medicine, Dermatology Division, David Geffen School of Medicine at the University of California, Los Angeles, CaliforniaAbstract: Shingles, also known as herpes zoster, is a common disease in the elderly ...
Jamie Zussman, Lorraine Young
doaj
Clinical Kidney Journal, 2012 A 66-year-old man who had end-stage renal disease and was undergoing maintenance hemodialysis presented with facial edema together with a strip of blisters and crust over the right side of his reddened forehead. Initially, the symptoms seemed indicative of herpes zoster ophthalmicus. However, his left periorbital area was more swollen than the infected
Neild, G. H. +4 more
openaire +2 more sources
De-pollution efficacy of photocatalytic roofing granules [PDF]
, 2019 Photocatalytic building surfaces can harness sunlight to reduce urban air pollution. The NOx abatement capacity of TiO2-coated granules used in roofing products was evaluated for commercial product development.
Ban-Weiss, G +12 more
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The far-ultraviolet spectra of two hot PG1159 stars
, 2016 PG1159 stars are hot, hydrogen-deficient (pre-) white dwarfs with atmospheres mainly composed of helium, carbon, and oxygen. The unusual surface chemistry is the result of a late helium-shell flash.
Kruk, J. W., Rauch, T., Werner, K.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source