Varicella zoster virus mRNA vaccine candidate induced superior cellular immunity and comparable humoral and Fc-mediated immunity compared to the licensed subunit vaccine in a mouse model [PDF]
Human Vaccines & ImmunotherapeuticsThe threat of herpes zoster (HZ) is increasing, particularly in the elderly and immunocompromised individuals. Although two platform vaccines are currently available for HZ prevention, the low effectiveness of the live attenuated varicella-zoster virus ...
Eun-Jeong Jang +13 more
doaj +3 more sources
Myasthenia Gravis Exacerbation with Shingrix Vaccine
RRNMF Neuromuscular Journal, 2020 Lakshmi Digala, Raghav Govindarjan
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Evaluation of Shingrix vaccine against Herpes Zoster
, 2022 1 BACKGROUND 18 -- 1.1 HERPES ZOSTER .18 -- 1.2 TREATMENT .20 -- 1.3 VACCINE .21 -- 2 RESEARCH QUESTIONS .22 -- 3 BURDEN OF DISEASE OF HZ IN BELGIUM .22 -- 3.1 METHODS 22 -- 3.2 INCIDENCE OF HZ 22 -- 3.2.1 Belgian data 23 -- 3.2.2 International data .34 -- 3.2.3 Risk of recurrence 42 -- 3.2.4 Discussion 42 -- 3.3 INCIDENCE OF POSTHERPETIC NEURALGIA ...
Dominique, Roberfroid +3 more
core +5 more sources
Identification and Characterization of CD4 + T Cell Epitopes after Shingrix Vaccination [PDF]
Journal of Virology, 2020 Understanding the T cell profile associated with the protection observed in elderly vaccinees following Shingrix vaccination is relevant to the general definition of correlates of vaccine efficacy. Our study enables these future studies by clarifying the patterns of immunodominance associated with Shingrix vaccination, as opposed to natural infection ...
Hannah Voic +10 more
openaire +5 more sources
Viruses, 2023 Herpes zoster (HZ) is a disease caused by the reactivation of latent varicella-zoster virus (VZV). The subunit vaccine, Shingrix®, and live attenuated vaccine, Zostavax®, could be used as an HZ vaccine that prevents HZ from being developed due to the ...
Yanpeng Zheng +8 more
doaj +2 more sources
Antisynthetase Syndrome Post Shingrix and Pneumovax Vaccinations, Possible Correlation
Cureus, 2022 This is a case report of a patient who developed acute progressive shortness of breath that started two days following the administration of Shingrix and Pneumovax vaccinations. Eight days after the onset of his symptoms he was diagnosed with acute interstitial pneumonitis based on CT scan of the chest which later appeared to be consistent with the ...
Osman, Alsayed +3 more
exaly +3 more sources
A critical appraisal of ‘Shingrix’, a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus [PDF]
Human Vaccines & Immunotherapeutics, 2017 HZ/Su, branded as ‘Shingrix’, is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, a global concern with aging populations. A live attenuated vaccine for shingles has been available for
Tehmina Bharucha +2 more
doaj +2 more sources
TLR9 and STING agonists adjuvanted varicella-zoster virus glycoprotein E induced a potent and durable nasal vaccine response [PDF]
Human Vaccines & ImmunotherapeuticsHerpes zoster is caused by the reactivation of latent varicella-zoster virus (VZV), primarily affecting middle-aged and older individuals and often accompanied by severe pain and other complications. Vaccination is an effective preventive measure against
Jing-Xing Yang +13 more
doaj +2 more sources
A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine [PDF]
Frontiers in ImmunologyIntroductionReactivation of the varicella-zoster virus (VZV) results in herpes zoster (HZ), which can lead to complications such as postherpetic neuralgia. The commercially available HZ subunit adjuvanted vaccine, Shingrix®, offers significant protection
Zihan Wang +16 more
doaj +2 more sources
Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice [PDF]
Journal of NanobiotechnologyHerpes zoster (HZ), commonly known as shingles, arises from the reactivation of the latent varicella-zoster virus (VZV) when VZV-specific cellular immunity declines below a critical threshold necessary for viral suppression.
Sibo Zhang +19 more
doaj +2 more sources